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- W2105783325 abstract "Summary Context Osteocalcin is associated with energy metabolism and atherosclerosis, besides bone metabolism. However, the association between osteocalcin or its undercarboxylated form (uc OC ) and coronary artery calcification is controversial. Objective To evaluate the relationship between coronary artery calcium score ( CACS ) and the concentration of serum osteocalcin and uc OC . Design Cross‐sectional. Patients A total of 162 subjects (114 men and 48 women) with no angina symptom. Measurements Serum analyses included glucose, insulin and lipid profiles as well as osteocalcin and uc OC . Bone mineral density ( BMD ) was measured by dual X‐ray absorptiometry. CACS was measured using multidetector computed tomography and categorized into CACS = 0 and CACS > 0. Results The mean osteocalcin concentration in men was 15·6 ± 4·2 for CACS = 0 group and 14·1 ± 4·0 for CACS > 0 group, respectively ( P = 0·050). In women, the osteocalcin concentration, uc OC concentration and uc OC to osteocalcin ratio ( OCR ) were not different between the CACS groups. However, the concentrations of osteocalcin and uc OC were significantly lower in women with hypertension or diabetes than those without, respectively. In the multivariate logistic regression models adjusted for medical history, body mass index, lipid profiles, insulin resistance and BMD in men, the higher concentration of uc OC and higher OCR showed significant association with coronary calcification ( CACS > 0). Conclusion Higher uc OC concentration was associated with coronary artery calcification independent of conventional cardiovascular risk factors and BMD in men." @default.
- W2105783325 created "2016-06-24" @default.
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- W2105783325 date "2015-04-27" @default.
- W2105783325 modified "2023-10-02" @default.
- W2105783325 title "Coronary artery calcification is associated with high serum concentration of undercarboxylated osteocalcin in asymptomatic Korean men" @default.
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- W2105783325 doi "https://doi.org/10.1111/cen.12792" @default.
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