FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105803100> ?p ?o ?g. }

• W2105803100 endingPage "40" @default.
• W2105803100 startingPage "4233" @default.
• W2105803100 abstract "Clotrimazole, a topically applied imidazole antifungal agent widely used in dermatological practice, was shown to be a potent inhibitor of the epidermal metabolism of benzo(a)pyrene (BP) and its microsomal enzyme-mediated binding both to neonatal rat epidermal DNA in vivo and to calf thymus DNA in vitro. Varying concentrations of clotrimazole added to in vitro incubation systems resulted in a dose-dependent inhibition of cytochrome P-450-dependent microsomal aryl hydrocarbon hydroxylase (AHH) in control animals as well as in animals pretreated with topical application of known inducers of the enzyme. Inhibition of epidermal AHH by topically applied clotrimazole was time and dose dependent. The 50% inhibition of clotrimazole for epidermal AHH ranged from 0.12 to 0.25 microM, which suggests that clotrimazole is among the most potent inhibitors of epidermal AHH yet identified. Clotrimazole was also found to be a potent inhibitor of epoxide hydrolase activity in vitro with a 50% inhibition at 0.1 mM. High-pressure liquid chromatographic analysis of the metabolism of BP in rat epidermal microsomes revealed substantial inhibition of metabolite formation by clotrimazole. This occurred in microsomes prepared from untreated as well as animals pretreated with inducers of the enzyme. Furthermore, a single topical application of clotrimazole resulted in 80 and 30% induction of epidermal and hepatic glutathione S-transferase activity, respectively. Topical application of clotrimazole to the skin of BALB/c mice substantially increased the latent period for the development of skin tumors by 3-methylcholanthrene. These studies indicate that clotrimazole is an extremely potent inhibitor of epidermal BP metabolism and of the DNA-binding of polycyclic aromatic hydrocarbon (PAH) carcinogens, and is an enhancer of enzymes necessary for detoxification of the PAH. Clotrimazole also reduces the formation of carcinogenic and mutagenic metabolites of BP in vitro and in vivo and inhibits induction of skin tumors by the PAH. These data indicate that the imidazole antifungal clotrimazole offers promise as an agent useful for the modulation of PAH cancer risk in the skin." @default.
• W2105803100 created "2016-06-24" @default.
• W2105803100 creator A5001770460 @default.
• W2105803100 creator A5025614590 @default.
• W2105803100 creator A5027382896 @default.
• W2105803100 creator A5055377535 @default.
• W2105803100 creator A5073294758 @default.
• W2105803100 creator A5082425428 @default.
• W2105803100 date "1984-10-01" @default.
• W2105803100 modified "2023-09-26" @default.
• W2105803100 title "Clotrimazole, an inhibitor of epidermal benzo(a)pyrene metabolism and DNA binding and carcinogenicity of the hydrocarbon." @default.
• W2105803100 cites W1525325861 @default.
• W2105803100 cites W1542868541 @default.
• W2105803100 cites W1581414347 @default.
• W2105803100 cites W1701599069 @default.
• W2105803100 cites W1775749144 @default.
• W2105803100 cites W1978382373 @default.
• W2105803100 cites W1984713897 @default.
• W2105803100 cites W1989852001 @default.
• W2105803100 cites W1999874510 @default.
• W2105803100 cites W2004289684 @default.
• W2105803100 cites W2017682851 @default.
• W2105803100 cites W2019605110 @default.
• W2105803100 cites W2052812478 @default.
• W2105803100 cites W2088339285 @default.
• W2105803100 cites W2396001775 @default.
• W2105803100 cites W2400873740 @default.
• W2105803100 cites W2463389471 @default.
• W2105803100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6088034" @default.
• W2105803100 hasPublicationYear "1984" @default.
• W2105803100 type Work @default.
• W2105803100 sameAs 2105803100 @default.
• W2105803100 citedByCount "9" @default.
• W2105803100 countsByYear W21058031002018 @default.
• W2105803100 crossrefType "journal-article" @default.
• W2105803100 hasAuthorship W2105803100A5001770460 @default.
• W2105803100 hasAuthorship W2105803100A5025614590 @default.
• W2105803100 hasAuthorship W2105803100A5027382896 @default.
• W2105803100 hasAuthorship W2105803100A5055377535 @default.
• W2105803100 hasAuthorship W2105803100A5073294758 @default.
• W2105803100 hasAuthorship W2105803100A5082425428 @default.
• W2105803100 hasConcept C114246631 @default.
• W2105803100 hasConcept C132154277 @default.
• W2105803100 hasConcept C181199279 @default.
• W2105803100 hasConcept C185592680 @default.
• W2105803100 hasConcept C202751555 @default.
• W2105803100 hasConcept C2777477808 @default.
• W2105803100 hasConcept C2778793413 @default.
• W2105803100 hasConcept C2779548794 @default.
• W2105803100 hasConcept C2780628323 @default.
• W2105803100 hasConcept C55493867 @default.
• W2105803100 hasConcept C86803240 @default.
• W2105803100 hasConcept C87644729 @default.
• W2105803100 hasConcept C89423630 @default.
• W2105803100 hasConcept C98274493 @default.
• W2105803100 hasConceptScore W2105803100C114246631 @default.
• W2105803100 hasConceptScore W2105803100C132154277 @default.
• W2105803100 hasConceptScore W2105803100C181199279 @default.
• W2105803100 hasConceptScore W2105803100C185592680 @default.
• W2105803100 hasConceptScore W2105803100C202751555 @default.
• W2105803100 hasConceptScore W2105803100C2777477808 @default.
• W2105803100 hasConceptScore W2105803100C2778793413 @default.
• W2105803100 hasConceptScore W2105803100C2779548794 @default.
• W2105803100 hasConceptScore W2105803100C2780628323 @default.
• W2105803100 hasConceptScore W2105803100C55493867 @default.
• W2105803100 hasConceptScore W2105803100C86803240 @default.
• W2105803100 hasConceptScore W2105803100C87644729 @default.
• W2105803100 hasConceptScore W2105803100C89423630 @default.
• W2105803100 hasConceptScore W2105803100C98274493 @default.
• W2105803100 hasIssue "10" @default.
• W2105803100 hasLocation W21058031001 @default.
• W2105803100 hasOpenAccess W2105803100 @default.
• W2105803100 hasPrimaryLocation W21058031001 @default.
• W2105803100 hasRelatedWork W1756199644 @default.
• W2105803100 hasRelatedWork W1910058334 @default.
• W2105803100 hasRelatedWork W1973983361 @default.
• W2105803100 hasRelatedWork W1974165727 @default.
• W2105803100 hasRelatedWork W1979584028 @default.
• W2105803100 hasRelatedWork W1991113392 @default.
• W2105803100 hasRelatedWork W1993978947 @default.
• W2105803100 hasRelatedWork W2054408934 @default.
• W2105803100 hasRelatedWork W2071690921 @default.
• W2105803100 hasRelatedWork W3145479628 @default.
• W2105803100 hasVolume "44" @default.
• W2105803100 isParatext "false" @default.
• W2105803100 isRetracted "false" @default.
• W2105803100 magId "2105803100" @default.
• W2105803100 workType "article" @default.