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- W2105810010 abstract "We used an isometric muscle preparation to test the hypothesis that yellowfin tuna Thunnus albacares utilize the intracellular Ca2+ storage sites of the sarcoplasmic reticulum (SR) during routine contractions. Ryanodine (a blocker of SR Ca2+ release) reduced the force of contraction by approximately 50 % and the rates of contraction and relaxation by 60 % in yellowfin tuna atrium. High levels of adrenaline were unable to ameliorate the effects of ryanodine. We conclude that the SR is active in contributing Ca2+ to force development at physiological contraction frequencies. Further, we suggest that, by using intracellular Ca2+ cycling, the yellowfin tuna is able to increase the maximum contraction frequency of its cardiac muscle beyond that of most other fishes." @default.
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- W2105810010 date "1999-04-01" @default.
- W2105810010 modified "2023-09-27" @default.
- W2105810010 title "The sarcoplasmic reticulum plays a major role in isometric contraction in atrial muscle of yellowfin tuna" @default.
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- W2105810010 doi "https://doi.org/10.1242/jeb.202.7.881" @default.
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