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- W2105811764 abstract "Magnetic manipulation, fluorescent tracking, and localized delivery of a drug payload to cancer cells in vitro is demonstrated, using nanostructured porous silicon microparticles as a carrier. The multifunctional microparticles are prepared by electrochemical porosification of a silicon wafer in a hydrofluoric acid-containing electrolyte, followed by removal and fracture of the porous layer into particles using ultrasound. The intrinsically luminescent particles are loaded with superparamagnetic iron oxide nanoparticles and the anti-cancer drug doxorubicin. The drug-containing particles are delivered to human cervical cancer (HeLa) cells in vitro, under the guidance of a magnetic field. The high concentration of particles in the proximity of the magnetic field results in a high concentration of drug being released in that region of the Petri dish, and localized cell death is confirmed by cellular viability assay (Calcein AM)." @default.
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- W2105811764 date "2010-09-02" @default.
- W2105811764 modified "2023-10-09" @default.
- W2105811764 title "Magnetic Luminescent Porous Silicon Microparticles for Localized Delivery of Molecular Drug Payloads" @default.
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- W2105811764 doi "https://doi.org/10.1002/smll.201000841" @default.
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