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- W2105818915 abstract "Peripheral counts of CD16(+ ) NK cells have been well characterized in reproductive failure. However, not enough case-control clinical studies have been conducted to establish normal or abnormal CD16(+/-) values in the endometrium.Peripheral and endometrial NK cell counts by FACS, IL-6, and VEGF cytokines levels by ELISA were characterized in fertile women and unexplained infertility patients with implantation failures (UI-IF) during implantation window. ROC and correlation analysis were performed.Receiver Operating Characteristic(ROC) analysis revealed endometrial CD16(+ ) NK cells, IL-6, and VEGF as good diagnostic parameters for unexplained infertility. Almost half of UI-FI patients showed increased total and CD16(+ ) NK cell counts correlating with decreased levels of endometrial IL-6 and VEGF. No correlation was found with peripheral blood values.Increased CD16(+ ) NK cells were associated with IL-6 and VEGF deficiency in a high proportion of UI-IF patients. Testing for these immunomarkers could be a potential tool in infertility diagnosis." @default.
- W2105818915 created "2016-06-24" @default.
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- W2105818915 date "2013-05-06" @default.
- W2105818915 modified "2023-09-27" @default.
- W2105818915 title "Endometrial CD16<sup>+</sup>and CD16<sup>−</sup>NK Cell Count in Fertility and Unexplained Infertility" @default.
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- W2105818915 doi "https://doi.org/10.1111/aji.12132" @default.
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