FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105848323> ?p ?o ?g. }

• W2105848323 endingPage "1776" @default.
• W2105848323 startingPage "1773" @default.
• W2105848323 abstract "The stationary phase of Clostridium difficile, which is associated with the symptoms of the diarrhoeal disease, is refractory to antibiotic killing. The aim of this study was to explore whether probiotic-derived reutericyclin and related synthetic analogues could kill stationary phase C. difficile at concentrations achievable in the gastrointestinal tract.The bactericidal activities of reutericyclin and lead compound derivatives were examined against logarithmic and stationary phase cultures of different C. difficile strains. The absorption of compounds across the intestinal epithelia was tested using the Caco-2 permeability model.Unlike vancomycin and metronidazole, reutericyclins demonstrated concentration-dependent killing, being rapidly bactericidal against both logarithmic and stationary phase cells, at low concentrations (0.09-2 mg/L). The intestinal absorption of unmodified reutericyclin was poor and comparable to that of vancomycin. However, this property varied significantly for the synthetic reutericyclin analogues, ranging from well absorbed to non-absorbed. The non-absorbable compounds were highly effluxed, suggesting this parameter could be modulated to obtain agents with superior efficacy.Reutericyclins showed excellent potency against the lethal non-growing stage of C. difficile at concentrations that may be attained in the gastrointestinal tract. Since these agents represent novel potential treatments for C. difficile infection, further development of this compound class is warranted." @default.
• W2105848323 created "2016-06-24" @default.
• W2105848323 creator A5008410969 @default.
• W2105848323 creator A5027892233 @default.
• W2105848323 creator A5056547217 @default.
• W2105848323 creator A5079294349 @default.
• W2105848323 creator A5081453369 @default.
• W2105848323 date "2011-05-31" @default.
• W2105848323 modified "2023-10-10" @default.
• W2105848323 title "Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations" @default.
• W2105848323 cites W1963485527 @default.
• W2105848323 cites W1989761771 @default.
• W2105848323 cites W2032679787 @default.
• W2105848323 cites W2097248275 @default.
• W2105848323 cites W2106993534 @default.
• W2105848323 cites W2115981806 @default.
• W2105848323 cites W2135517360 @default.
• W2105848323 cites W2142802863 @default.
• W2105848323 cites W2163423623 @default.
• W2105848323 doi "https://doi.org/10.1093/jac/dkr201" @default.
• W2105848323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3133486" @default.
• W2105848323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21632577" @default.
• W2105848323 hasPublicationYear "2011" @default.
• W2105848323 type Work @default.
• W2105848323 sameAs 2105848323 @default.
• W2105848323 citedByCount "27" @default.
• W2105848323 countsByYear W21058483232012 @default.
• W2105848323 countsByYear W21058483232013 @default.
• W2105848323 countsByYear W21058483232014 @default.
• W2105848323 countsByYear W21058483232015 @default.
• W2105848323 countsByYear W21058483232016 @default.
• W2105848323 countsByYear W21058483232017 @default.
• W2105848323 countsByYear W21058483232018 @default.
• W2105848323 countsByYear W21058483232021 @default.
• W2105848323 countsByYear W21058483232022 @default.
• W2105848323 countsByYear W21058483232023 @default.
• W2105848323 crossrefType "journal-article" @default.
• W2105848323 hasAuthorship W2105848323A5008410969 @default.
• W2105848323 hasAuthorship W2105848323A5027892233 @default.
• W2105848323 hasAuthorship W2105848323A5056547217 @default.
• W2105848323 hasAuthorship W2105848323A5079294349 @default.
• W2105848323 hasAuthorship W2105848323A5081453369 @default.
• W2105848323 hasBestOaLocation W21058483231 @default.
• W2105848323 hasConcept C125287762 @default.
• W2105848323 hasConcept C159985019 @default.
• W2105848323 hasConcept C185592680 @default.
• W2105848323 hasConcept C192562407 @default.
• W2105848323 hasConcept C2777396551 @default.
• W2105848323 hasConcept C2778980435 @default.
• W2105848323 hasConcept C2779489039 @default.
• W2105848323 hasConcept C2780512811 @default.
• W2105848323 hasConcept C2781092032 @default.
• W2105848323 hasConcept C2994496256 @default.
• W2105848323 hasConcept C501593827 @default.
• W2105848323 hasConcept C523546767 @default.
• W2105848323 hasConcept C54355233 @default.
• W2105848323 hasConcept C55493867 @default.
• W2105848323 hasConcept C86803240 @default.
• W2105848323 hasConcept C89423630 @default.
• W2105848323 hasConcept C98274493 @default.
• W2105848323 hasConceptScore W2105848323C125287762 @default.
• W2105848323 hasConceptScore W2105848323C159985019 @default.
• W2105848323 hasConceptScore W2105848323C185592680 @default.
• W2105848323 hasConceptScore W2105848323C192562407 @default.
• W2105848323 hasConceptScore W2105848323C2777396551 @default.
• W2105848323 hasConceptScore W2105848323C2778980435 @default.
• W2105848323 hasConceptScore W2105848323C2779489039 @default.
• W2105848323 hasConceptScore W2105848323C2780512811 @default.
• W2105848323 hasConceptScore W2105848323C2781092032 @default.
• W2105848323 hasConceptScore W2105848323C2994496256 @default.
• W2105848323 hasConceptScore W2105848323C501593827 @default.
• W2105848323 hasConceptScore W2105848323C523546767 @default.
• W2105848323 hasConceptScore W2105848323C54355233 @default.
• W2105848323 hasConceptScore W2105848323C55493867 @default.
• W2105848323 hasConceptScore W2105848323C86803240 @default.
• W2105848323 hasConceptScore W2105848323C89423630 @default.
• W2105848323 hasConceptScore W2105848323C98274493 @default.
• W2105848323 hasIssue "8" @default.
• W2105848323 hasLocation W21058483231 @default.
• W2105848323 hasLocation W21058483232 @default.
• W2105848323 hasLocation W21058483233 @default.
• W2105848323 hasLocation W21058483234 @default.
• W2105848323 hasOpenAccess W2105848323 @default.
• W2105848323 hasPrimaryLocation W21058483231 @default.
• W2105848323 hasRelatedWork W1963553950 @default.
• W2105848323 hasRelatedWork W2065362433 @default.
• W2105848323 hasRelatedWork W2092120669 @default.
• W2105848323 hasRelatedWork W2096350108 @default.
• W2105848323 hasRelatedWork W2144890361 @default.
• W2105848323 hasRelatedWork W2148529820 @default.
• W2105848323 hasRelatedWork W2410840307 @default.
• W2105848323 hasRelatedWork W2618744742 @default.
• W2105848323 hasRelatedWork W3055073817 @default.
• W2105848323 hasRelatedWork W3151500413 @default.
• W2105848323 hasVolume "66" @default.
• W2105848323 isParatext "false" @default.
• W2105848323 isRetracted "false" @default.
• W2105848323 magId "2105848323" @default.

• next