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• W2105850967 abstract "“This is the best job in academic medicine”, proclaims Larry Jameson, who has been Executive Vice President for the Health System and Dean of the Perelman School of Medicine at the University of Pennsylvania since 2011. On May 16, 2015, Jameson will lead the celebrations to commemorate the 250th anniversary of what is the oldest medical school in the USA.Being both Executive Vice President and Dean is becoming increasingly common within the US medical arena. The dual role has Jameson leading an integrated health system, referred to as Penn Medicine, which encompasses the medical school, biomedical research programmes, and the university's hospitals. “This integrated model in the current era of translational medicine allows us to accelerate research and make transformative advances that impact patient care”, Jameson explains. “We want to inform the questions the scientists ask with the clinical problems the physicians are facing, so that science yields impactful discoveries and solutions. I think we are succeeding very well in this approach, especially in the past 15 years, where research has become sharpened by our clinical focus”, he adds. With his overarching role, Jameson has a direct line to the chairs of clinical departments, the heads of basic science departments, and directors of the school's science centres and institutes. “I can interact with basic scientists and clinical leads, which is fascinating and important to sustain the collaborative culture in which translational medicine thrives”, he says. His own background as a physician scientist in molecular endocrinology equips him well for this task.Back in the early 1990s, having moved to Northwestern University in Chicago as Head of Endocrinology, Jameson's research priority was to help advance recombinant DNA technology and genetics at the medical centre. “The technological change in molecular endocrinology in the 1990s was stunning”, he recalls. “A decade before, it could take 2 or 3 years to isolate and sequence a gene that was causing an endocrine disorder. During my time at Northwestern, this changed to being a few days' work.” Jameson's career as a physician scientist is exemplified by his research into the use of recombinant DNA that helped to identify the genetic causes and pathophysiology of many endocrine disorders, notably his work involving steroidogenic factor 1 and its role in adrenal insufficiency and reproductive disorders. “With a better molecular understanding of disease, we can now categorise conditions more subtly than before, and this type of precision medicine helps us tailor treatments”, he says.If 18 years at Northwestern was transformative for Jameson, then so was his early career at Boston's Massachusetts General Hospital in the 1980s. For here he realised that his conventional tuition in biochemistry from his time at the University of North Carolina was about to be turned upside down by the evolution of recombinant DNA technology. “Mass Gen was a spectacular environment, supporting physician scientists while also offering clinical excellence”, Jameson recalls. “I spent 12 wonderful years in that environment, including work in the thyroid unit there”.For someone who has risen to the top of academic medicine, it is curious to discover that Jameson set out on an academic path that did not have science or medicine in its sights. Brought up in a non-academic family, and schooled in an environment “where you kept quiet if you got an A grade in anything”, Jameson gained an undergraduate degree in biochemistry from the University of North Carolina at Chapel Hill. It was while spending a summer on a biochemistry research programme “to avoid going home and doing night shifts at my father's wholesale grocery business”, that he developed the desire for more study, enrolling at Chapel Hill for both PhD biochemistry and medicine. “My research experience at Chapel Hill shaped where I wanted to go”, he says, “and while little of my time there was planned, it was the opportunity of engaging with great minds, such as Francis Collins, who was a chief medical resident at the time. He foresaw the potential of genetics to find the cause of diseases like cystic fibrosis and inspired me to move in that direction.”Looking ahead, Jameson believes that informatics is an emerging area that could transform clinical research and practice. “We are at an early stage in using systems such as smart medical records and data-mining tools to help doctors in clinical decision making, and to use informatics to reshape the way we do clinical trials”, he says. “We will increasingly realise the benefits of the Human Genome Project and its rich information base for pathophysiology of disease, but this will take time”, he adds.250 years ago, it was the vision of the physician John Morgan who, influenced by his medical studies in Europe, saw the need to join up classroom teaching with bedside instruction, as well as the convergence of early research with the education of young physicians. The USA's first medical school was born, and Jameson is only too aware of this immense milestone. “We are stewards of a rich legacy. The 250th anniversary is a moment to celebrate and reflect on our history in order to perpetuate its impact as we look to the future”, he says. “The highlight will be the opening of our new Henry A Jordan Medical Education Center, which, true to our ethos of integration, will sit above our clinics and be connected to our research labs. Our students will feel the connection between teaching, the lab, and the clinic throughout their time with us.” “This is the best job in academic medicine”, proclaims Larry Jameson, who has been Executive Vice President for the Health System and Dean of the Perelman School of Medicine at the University of Pennsylvania since 2011. On May 16, 2015, Jameson will lead the celebrations to commemorate the 250th anniversary of what is the oldest medical school in the USA. Being both Executive Vice President and Dean is becoming increasingly common within the US medical arena. The dual role has Jameson leading an integrated health system, referred to as Penn Medicine, which encompasses the medical school, biomedical research programmes, and the university's hospitals. “This integrated model in the current era of translational medicine allows us to accelerate research and make transformative advances that impact patient care”, Jameson explains. “We want to inform the questions the scientists ask with the clinical problems the physicians are facing, so that science yields impactful discoveries and solutions. I think we are succeeding very well in this approach, especially in the past 15 years, where research has become sharpened by our clinical focus”, he adds. With his overarching role, Jameson has a direct line to the chairs of clinical departments, the heads of basic science departments, and directors of the school's science centres and institutes. “I can interact with basic scientists and clinical leads, which is fascinating and important to sustain the collaborative culture in which translational medicine thrives”, he says. His own background as a physician scientist in molecular endocrinology equips him well for this task. Back in the early 1990s, having moved to Northwestern University in Chicago as Head of Endocrinology, Jameson's research priority was to help advance recombinant DNA technology and genetics at the medical centre. “The technological change in molecular endocrinology in the 1990s was stunning”, he recalls. “A decade before, it could take 2 or 3 years to isolate and sequence a gene that was causing an endocrine disorder. During my time at Northwestern, this changed to being a few days' work.” Jameson's career as a physician scientist is exemplified by his research into the use of recombinant DNA that helped to identify the genetic causes and pathophysiology of many endocrine disorders, notably his work involving steroidogenic factor 1 and its role in adrenal insufficiency and reproductive disorders. “With a better molecular understanding of disease, we can now categorise conditions more subtly than before, and this type of precision medicine helps us tailor treatments”, he says. If 18 years at Northwestern was transformative for Jameson, then so was his early career at Boston's Massachusetts General Hospital in the 1980s. For here he realised that his conventional tuition in biochemistry from his time at the University of North Carolina was about to be turned upside down by the evolution of recombinant DNA technology. “Mass Gen was a spectacular environment, supporting physician scientists while also offering clinical excellence”, Jameson recalls. “I spent 12 wonderful years in that environment, including work in the thyroid unit there”. For someone who has risen to the top of academic medicine, it is curious to discover that Jameson set out on an academic path that did not have science or medicine in its sights. Brought up in a non-academic family, and schooled in an environment “where you kept quiet if you got an A grade in anything”, Jameson gained an undergraduate degree in biochemistry from the University of North Carolina at Chapel Hill. It was while spending a summer on a biochemistry research programme “to avoid going home and doing night shifts at my father's wholesale grocery business”, that he developed the desire for more study, enrolling at Chapel Hill for both PhD biochemistry and medicine. “My research experience at Chapel Hill shaped where I wanted to go”, he says, “and while little of my time there was planned, it was the opportunity of engaging with great minds, such as Francis Collins, who was a chief medical resident at the time. He foresaw the potential of genetics to find the cause of diseases like cystic fibrosis and inspired me to move in that direction.” Looking ahead, Jameson believes that informatics is an emerging area that could transform clinical research and practice. “We are at an early stage in using systems such as smart medical records and data-mining tools to help doctors in clinical decision making, and to use informatics to reshape the way we do clinical trials”, he says. “We will increasingly realise the benefits of the Human Genome Project and its rich information base for pathophysiology of disease, but this will take time”, he adds. 250 years ago, it was the vision of the physician John Morgan who, influenced by his medical studies in Europe, saw the need to join up classroom teaching with bedside instruction, as well as the convergence of early research with the education of young physicians. The USA's first medical school was born, and Jameson is only too aware of this immense milestone. “We are stewards of a rich legacy. The 250th anniversary is a moment to celebrate and reflect on our history in order to perpetuate its impact as we look to the future”, he says. “The highlight will be the opening of our new Henry A Jordan Medical Education Center, which, true to our ethos of integration, will sit above our clinics and be connected to our research labs. Our students will feel the connection between teaching, the lab, and the clinic throughout their time with us.” The first American medical school: the formative yearsIn 1765, students were admitted to “anatomical lectures” and a course on “the theory and practice of physik” at the College of Philadelphia. Thus began the first medical school in the USA—at that time, of course, “America” simply consisted of 13 colonies. Eventually, after various convulsions and name changes, the College of Philadelphia would transmute into the University of Pennsylvania and the two courses of lectures into the university's Perelman School of Medicine. Full-Text PDF" @default.
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• W2105850967 title "Larry Jameson: at the helm of the USA's oldest medical school" @default.
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