Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105850998> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2105850998 endingPage "151" @default.
- W2105850998 startingPage "141" @default.
- W2105850998 abstract "Glioblastomas are generally thought to be more common in men than in women. In erder to investigate the hormone-dependence of these tumours, we established a human glioblastoma line in athymic mice. The tumour cell type was characterized using immunocyto-chemical methods. The influence of host sex on growth was evaluated, and hormone receptors were characterized biochemically. The histological features of the initial tumour were conserved in the hetero-transplanted tumours, which consisted of vimentin and GFAP immunoreactive astrocytes. There was a highly significant difference in tumour growth between the two sexes (P < 0.01). In the male mice, tumours were from 2.5 to 10 times larger than in the females, the latency periods were 30% shorter, and the growth phases were characterized by periods of slow or zero growth. In addition, androgen and oestrogen receptors were detected at low levels (80–270 fmol/g tumour) in the heterotransplanted tumours especially in the males. The fact that the male tumour growth profiles resembled those of some hormone-dependent lines, and that androgen receptors were found preferentially in the male rather than in female tumours would tend to indicate that there is a hormonal influence on the growth of the heterotransplanted tumours. These results provide further evidence for an influence of sex-steroid hormones on the growth of glioblastomas." @default.
- W2105850998 created "2016-06-24" @default.
- W2105850998 creator A5004297012 @default.
- W2105850998 creator A5036647974 @default.
- W2105850998 creator A5050925006 @default.
- W2105850998 creator A5087434998 @default.
- W2105850998 date "1990-04-01" @default.
- W2105850998 modified "2023-10-18" @default.
- W2105850998 title "Influence of host sex on the growth of a human glioblastoma line in athymic mice" @default.
- W2105850998 cites W1983649348 @default.
- W2105850998 cites W1986431946 @default.
- W2105850998 cites W1988522657 @default.
- W2105850998 cites W2007600417 @default.
- W2105850998 cites W2032552530 @default.
- W2105850998 cites W2036254582 @default.
- W2105850998 cites W2044110633 @default.
- W2105850998 cites W2044447938 @default.
- W2105850998 cites W2051996964 @default.
- W2105850998 cites W2055390759 @default.
- W2105850998 cites W2069532293 @default.
- W2105850998 cites W2076458959 @default.
- W2105850998 cites W2083298609 @default.
- W2105850998 cites W2109523793 @default.
- W2105850998 cites W2123748731 @default.
- W2105850998 doi "https://doi.org/10.1111/j.1365-2990.1990.tb00943.x" @default.
- W2105850998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2161085" @default.
- W2105850998 hasPublicationYear "1990" @default.
- W2105850998 type Work @default.
- W2105850998 sameAs 2105850998 @default.
- W2105850998 citedByCount "25" @default.
- W2105850998 countsByYear W21058509982012 @default.
- W2105850998 countsByYear W21058509982013 @default.
- W2105850998 countsByYear W21058509982014 @default.
- W2105850998 countsByYear W21058509982017 @default.
- W2105850998 countsByYear W21058509982018 @default.
- W2105850998 countsByYear W21058509982020 @default.
- W2105850998 countsByYear W21058509982021 @default.
- W2105850998 countsByYear W21058509982023 @default.
- W2105850998 crossrefType "journal-article" @default.
- W2105850998 hasAuthorship W2105850998A5004297012 @default.
- W2105850998 hasAuthorship W2105850998A5036647974 @default.
- W2105850998 hasAuthorship W2105850998A5050925006 @default.
- W2105850998 hasAuthorship W2105850998A5087434998 @default.
- W2105850998 hasConcept C121608353 @default.
- W2105850998 hasConcept C126322002 @default.
- W2105850998 hasConcept C134018914 @default.
- W2105850998 hasConcept C147447768 @default.
- W2105850998 hasConcept C170493617 @default.
- W2105850998 hasConcept C204232928 @default.
- W2105850998 hasConcept C2777911890 @default.
- W2105850998 hasConcept C2780192828 @default.
- W2105850998 hasConcept C61367390 @default.
- W2105850998 hasConcept C71315377 @default.
- W2105850998 hasConcept C71924100 @default.
- W2105850998 hasConcept C86803240 @default.
- W2105850998 hasConceptScore W2105850998C121608353 @default.
- W2105850998 hasConceptScore W2105850998C126322002 @default.
- W2105850998 hasConceptScore W2105850998C134018914 @default.
- W2105850998 hasConceptScore W2105850998C147447768 @default.
- W2105850998 hasConceptScore W2105850998C170493617 @default.
- W2105850998 hasConceptScore W2105850998C204232928 @default.
- W2105850998 hasConceptScore W2105850998C2777911890 @default.
- W2105850998 hasConceptScore W2105850998C2780192828 @default.
- W2105850998 hasConceptScore W2105850998C61367390 @default.
- W2105850998 hasConceptScore W2105850998C71315377 @default.
- W2105850998 hasConceptScore W2105850998C71924100 @default.
- W2105850998 hasConceptScore W2105850998C86803240 @default.
- W2105850998 hasIssue "2" @default.
- W2105850998 hasLocation W21058509981 @default.
- W2105850998 hasLocation W21058509982 @default.
- W2105850998 hasOpenAccess W2105850998 @default.
- W2105850998 hasPrimaryLocation W21058509981 @default.
- W2105850998 hasRelatedWork W1967664125 @default.
- W2105850998 hasRelatedWork W2012986564 @default.
- W2105850998 hasRelatedWork W2033566079 @default.
- W2105850998 hasRelatedWork W2051020921 @default.
- W2105850998 hasRelatedWork W2095348706 @default.
- W2105850998 hasRelatedWork W2104364640 @default.
- W2105850998 hasRelatedWork W2169608764 @default.
- W2105850998 hasRelatedWork W2327862400 @default.
- W2105850998 hasRelatedWork W2365928272 @default.
- W2105850998 hasRelatedWork W3009569511 @default.
- W2105850998 hasVolume "16" @default.
- W2105850998 isParatext "false" @default.
- W2105850998 isRetracted "false" @default.
- W2105850998 magId "2105850998" @default.
- W2105850998 workType "article" @default.