FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105863984> ?p ?o ?g. }

• W2105863984 endingPage "666" @default.
• W2105863984 startingPage "654" @default.
• W2105863984 abstract "<h3>OBJECTIVE:</h3> This meta-analysis was performed to evaluate the efficacy and safety of the addition of tiotropium to standard treatment regimens for inadequately controlled asthma. <h3>METHODS:</h3> A systematic search was made of PubMed, EMBASE, MEDLINE, and CENTRAL databases, and ClinicalTrials.gov, and a hand search of leading respiratory journals. Randomized, double-blind clinical trials on the treatment of inadequately controlled asthma for ≥ 4 weeks with the addition of tiotropium, compared with placebo, were reviewed. Studies were pooled to odds ratio (OR) and weighted mean differences (WMDs), with 95% CI. <h3>RESULTS:</h3> Six trials met the inclusion criteria. The addition of tiotropium, compared with placebo, significantly improved all spirometric indices, including morning and evening peak expiratory flow (WMD 20.59 L/min, 95% CI 15.36–25.81 L/min, <i>P</i> < .001; and WMD 24.95 L/min, 95% CI 19.22–30.69 L/min, <i>P</i> < .001, respectively), trough and peak FEV₁ (WMD 0.13 L, 95% CI 0.09–0.18 L, <i>P</i> < .001; and WMD 0.10 L, 95% CI 0.06–0.14 L, <i>P</i> < .001, respectively), the area under the curve of the first 3 h of FEV₁ (WMD 0.13 L, 95% CI 0.08–0.18 L, <i>P</i> < .001), trough and peak FVC (WMD 0.1 L, 95% CI 0.05–0.15 L, <i>P</i> < .001; and WMD 0.08 L, 95% CI 0.04–0.13 L, <i>P</i> < .001, respectively), the area under the curve of the first 3 h of FVC (WMD 0.11 L, 95% CI 0.06–0.15 L, <i>P</i> < .001). The mean change in the 7-point Asthma Control Questionnaire score (WMD −0.12, 95% CI −0.21 to −0.03, <i>P</i> = .01) was markedly lower in tiotropium group, but not clinically important. There were no significant differences in Asthma Quality of Life Questionnaire score (WMD 0.09, 95% CI −0.01 to 0.20, <i>P</i> = .09), night awakenings (WMD 0.00, 95% CI −0.05 to 0.05, <i>P</i> = .99) or rescue medication use (WMD −0.18, 95% CI −0.36 to 0.00, <i>P</i> = .06). No significant increase was noticed in adverse events in the tiotropium group (OR 0.80, 95% CI 0.62–1.03, <i>P</i> = .08). <h3>CONCLUSIONS:</h3> The addition of tiotropium to standard treatment regimens has significantly improved lung function without increasing adverse events in patients with inadequately controlled asthma. Long-term trials are required to assess the effects of the addition of tiotropium on asthma exacerbations and mortality." @default.
• W2105863984 created "2016-06-24" @default.
• W2105863984 creator A5040915613 @default.
• W2105863984 creator A5053453125 @default.
• W2105863984 creator A5065410299 @default.
• W2105863984 creator A5069544834 @default.
• W2105863984 date "2013-10-29" @default.
• W2105863984 modified "2023-10-17" @default.
• W2105863984 title "Tiotropium Versus Placebo for Inadequately Controlled Asthma: A Meta-Analysis" @default.
• W2105863984 cites W118021508 @default.
• W2105863984 cites W1730980153 @default.
• W2105863984 cites W1910738679 @default.
• W2105863984 cites W1932569518 @default.
• W2105863984 cites W1986215651 @default.
• W2105863984 cites W1987779503 @default.
• W2105863984 cites W2009191674 @default.
• W2105863984 cites W2066889593 @default.
• W2105863984 cites W2067589899 @default.
• W2105863984 cites W2067736395 @default.
• W2105863984 cites W2083407012 @default.
• W2105863984 cites W2103032229 @default.
• W2105863984 cites W2106698492 @default.
• W2105863984 cites W2107328434 @default.
• W2105863984 cites W2109215965 @default.
• W2105863984 cites W2116395845 @default.
• W2105863984 cites W2126325768 @default.
• W2105863984 cites W2137263772 @default.
• W2105863984 cites W2141034778 @default.
• W2105863984 cites W2148583736 @default.
• W2105863984 cites W2150634254 @default.
• W2105863984 cites W2158795682 @default.
• W2105863984 cites W2164297158 @default.
• W2105863984 cites W2278209875 @default.
• W2105863984 cites W2337220896 @default.
• W2105863984 cites W2401513323 @default.
• W2105863984 cites W387031605 @default.
• W2105863984 cites W56033953 @default.
• W2105863984 doi "https://doi.org/10.4187/respcare.02703" @default.
• W2105863984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24170916" @default.
• W2105863984 hasPublicationYear "2013" @default.
• W2105863984 type Work @default.
• W2105863984 sameAs 2105863984 @default.
• W2105863984 citedByCount "21" @default.
• W2105863984 countsByYear W21058639842014 @default.
• W2105863984 countsByYear W21058639842015 @default.
• W2105863984 countsByYear W21058639842016 @default.
• W2105863984 countsByYear W21058639842017 @default.
• W2105863984 countsByYear W21058639842019 @default.
• W2105863984 countsByYear W21058639842020 @default.
• W2105863984 countsByYear W21058639842022 @default.
• W2105863984 countsByYear W21058639842023 @default.
• W2105863984 crossrefType "journal-article" @default.
• W2105863984 hasAuthorship W2105863984A5040915613 @default.
• W2105863984 hasAuthorship W2105863984A5053453125 @default.
• W2105863984 hasAuthorship W2105863984A5065410299 @default.
• W2105863984 hasAuthorship W2105863984A5069544834 @default.
• W2105863984 hasBestOaLocation W21058639841 @default.
• W2105863984 hasConcept C126322002 @default.
• W2105863984 hasConcept C142724271 @default.
• W2105863984 hasConcept C156957248 @default.
• W2105863984 hasConcept C168563851 @default.
• W2105863984 hasConcept C19720800 @default.
• W2105863984 hasConcept C204787440 @default.
• W2105863984 hasConcept C27081682 @default.
• W2105863984 hasConcept C2776042228 @default.
• W2105863984 hasConcept C42219234 @default.
• W2105863984 hasConcept C71924100 @default.
• W2105863984 hasConcept C90924648 @default.
• W2105863984 hasConcept C95190672 @default.
• W2105863984 hasConceptScore W2105863984C126322002 @default.
• W2105863984 hasConceptScore W2105863984C142724271 @default.
• W2105863984 hasConceptScore W2105863984C156957248 @default.
• W2105863984 hasConceptScore W2105863984C168563851 @default.
• W2105863984 hasConceptScore W2105863984C19720800 @default.
• W2105863984 hasConceptScore W2105863984C204787440 @default.
• W2105863984 hasConceptScore W2105863984C27081682 @default.
• W2105863984 hasConceptScore W2105863984C2776042228 @default.
• W2105863984 hasConceptScore W2105863984C42219234 @default.
• W2105863984 hasConceptScore W2105863984C71924100 @default.
• W2105863984 hasConceptScore W2105863984C90924648 @default.
• W2105863984 hasConceptScore W2105863984C95190672 @default.
• W2105863984 hasIssue "5" @default.
• W2105863984 hasLocation W21058639841 @default.
• W2105863984 hasLocation W21058639842 @default.
• W2105863984 hasOpenAccess W2105863984 @default.
• W2105863984 hasPrimaryLocation W21058639841 @default.
• W2105863984 hasRelatedWork W2023731824 @default.
• W2105863984 hasRelatedWork W2059593117 @default.
• W2105863984 hasRelatedWork W2088444039 @default.
• W2105863984 hasRelatedWork W2100209961 @default.
• W2105863984 hasRelatedWork W3103904407 @default.
• W2105863984 hasRelatedWork W3159250744 @default.
• W2105863984 hasRelatedWork W4233016836 @default.
• W2105863984 hasRelatedWork W4256514411 @default.
• W2105863984 hasRelatedWork W4322724676 @default.
• W2105863984 hasRelatedWork W2903040050 @default.
• W2105863984 hasVolume "59" @default.
• W2105863984 isParatext "false" @default.

• next