FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105864694> ?p ?o ?g. }

• W2105864694 endingPage "951" @default.
• W2105864694 startingPage "937" @default.
• W2105864694 abstract "Inactivation of slow Ca2+ channels was studied in intact twitch skeletal muscle fibers of the frog by using the three-microelectrode voltage-clamp technique. Hypertonic sucrose solutions were used to abolish contraction. The rate constant of decay of the slow Ca2+ current (ICa) remained practically unchanged when the recording solution containing 10 mM Ca2+ was replaced by a Ca2+-buffered solution (126 mM Ca-maleate). The rate constant of decay of ICa monotonically increased with depolarization although the corresponding time integral of ICa followed a bell-shaped function. The replacement of Ca2+ by Ba2+ did not result in a slowing of the rate of decay of the inward current nor did it reduce the degree of steady-state inactivation. The voltage dependence of the steady-state inactivation curve was steeper in the presence of Ba2+. In two-pulse experiments with large conditioning depolarizations ICa inactivation remained unchanged although Ca2+ influx during the prepulse greatly decreased. Dantrolene (12 microM) increased mechanical threshold at all pulse durations tested, the effect being more prominent for short pulses. Dantrolene did not significantly modify ICa decay and the voltage dependence of inactivation. These results indicate that in intact muscle fibers Ca2+ channels inactivate in a voltage-dependent manner through a mechanism that does not require Ca2+ entry into the cell." @default.
• W2105864694 created "2016-06-24" @default.
• W2105864694 creator A5025979349 @default.
• W2105864694 creator A5061228775 @default.
• W2105864694 date "1989-11-01" @default.
• W2105864694 modified "2023-10-18" @default.
• W2105864694 title "Voltage-dependent inactivation of slow calcium channels in intact twitch muscle fibers of the frog." @default.
• W2105864694 cites W1513652054 @default.
• W2105864694 cites W1588468422 @default.
• W2105864694 cites W1956859188 @default.
• W2105864694 cites W1969612994 @default.
• W2105864694 cites W1974411391 @default.
• W2105864694 cites W1975364251 @default.
• W2105864694 cites W1987853199 @default.
• W2105864694 cites W1990125493 @default.
• W2105864694 cites W1993723682 @default.
• W2105864694 cites W2017138681 @default.
• W2105864694 cites W2019907746 @default.
• W2105864694 cites W2021636968 @default.
• W2105864694 cites W2032221526 @default.
• W2105864694 cites W2032674784 @default.
• W2105864694 cites W2038768965 @default.
• W2105864694 cites W2044667567 @default.
• W2105864694 cites W2045544906 @default.
• W2105864694 cites W2046110288 @default.
• W2105864694 cites W2059093744 @default.
• W2105864694 cites W2081623770 @default.
• W2105864694 cites W2090947749 @default.
• W2105864694 cites W2092204457 @default.
• W2105864694 cites W2095580565 @default.
• W2105864694 cites W2100955490 @default.
• W2105864694 cites W2106467866 @default.
• W2105864694 cites W2108156720 @default.
• W2105864694 cites W2128198680 @default.
• W2105864694 cites W2135413668 @default.
• W2105864694 cites W2145287037 @default.
• W2105864694 cites W2150530454 @default.
• W2105864694 cites W2156994958 @default.
• W2105864694 cites W2177590416 @default.
• W2105864694 cites W2199171951 @default.
• W2105864694 cites W2270770628 @default.
• W2105864694 cites W2299404966 @default.
• W2105864694 cites W2422894291 @default.
• W2105864694 cites W2427212431 @default.
• W2105864694 cites W591832344 @default.
• W2105864694 doi "https://doi.org/10.1085/jgp.94.5.937" @default.
• W2105864694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2228972" @default.
• W2105864694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2556496" @default.
• W2105864694 hasPublicationYear "1989" @default.
• W2105864694 type Work @default.
• W2105864694 sameAs 2105864694 @default.
• W2105864694 citedByCount "24" @default.
• W2105864694 countsByYear W21058646942012 @default.
• W2105864694 countsByYear W21058646942014 @default.
• W2105864694 countsByYear W21058646942020 @default.
• W2105864694 countsByYear W21058646942021 @default.
• W2105864694 crossrefType "journal-article" @default.
• W2105864694 hasAuthorship W2105864694A5025979349 @default.
• W2105864694 hasAuthorship W2105864694A5061228775 @default.
• W2105864694 hasBestOaLocation W21058646941 @default.
• W2105864694 hasConcept C100837961 @default.
• W2105864694 hasConcept C119599485 @default.
• W2105864694 hasConcept C12554922 @default.
• W2105864694 hasConcept C127413603 @default.
• W2105864694 hasConcept C178790620 @default.
• W2105864694 hasConcept C181911157 @default.
• W2105864694 hasConcept C185592680 @default.
• W2105864694 hasConcept C2781460320 @default.
• W2105864694 hasConcept C4141045 @default.
• W2105864694 hasConcept C519063684 @default.
• W2105864694 hasConcept C55493867 @default.
• W2105864694 hasConcept C81370116 @default.
• W2105864694 hasConcept C86803240 @default.
• W2105864694 hasConceptScore W2105864694C100837961 @default.
• W2105864694 hasConceptScore W2105864694C119599485 @default.
• W2105864694 hasConceptScore W2105864694C12554922 @default.
• W2105864694 hasConceptScore W2105864694C127413603 @default.
• W2105864694 hasConceptScore W2105864694C178790620 @default.
• W2105864694 hasConceptScore W2105864694C181911157 @default.
• W2105864694 hasConceptScore W2105864694C185592680 @default.
• W2105864694 hasConceptScore W2105864694C2781460320 @default.
• W2105864694 hasConceptScore W2105864694C4141045 @default.
• W2105864694 hasConceptScore W2105864694C519063684 @default.
• W2105864694 hasConceptScore W2105864694C55493867 @default.
• W2105864694 hasConceptScore W2105864694C81370116 @default.
• W2105864694 hasConceptScore W2105864694C86803240 @default.
• W2105864694 hasIssue "5" @default.
• W2105864694 hasLocation W21058646941 @default.
• W2105864694 hasLocation W21058646942 @default.
• W2105864694 hasLocation W21058646943 @default.
• W2105864694 hasLocation W21058646944 @default.
• W2105864694 hasOpenAccess W2105864694 @default.
• W2105864694 hasPrimaryLocation W21058646941 @default.
• W2105864694 hasRelatedWork W1966103370 @default.
• W2105864694 hasRelatedWork W1976128502 @default.
• W2105864694 hasRelatedWork W1989164968 @default.
• W2105864694 hasRelatedWork W1993251008 @default.
• W2105864694 hasRelatedWork W2062215334 @default.

• next