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- W2105871194 abstract "Abstract Identification of selective and synthetically tractable ligands to glycan‐binding proteins is important in glycoscience. Carbohydrate arrays have had a tremendous impact on profiling glycan‐binding proteins and as analytical tools. We report a highly miniaturized synthetic format to access nucleic‐acid‐encoded hetero‐glycoconjugate libraries with an unprecedented diversity in the combinations of glycans, linkers, and capping groups. Novel information about plant and bacterial lectin specificity was obtained by microarray profiling, and we show that a ligand identified on the array can be converted to a high‐affinity soluble ligand by straightforward chemistry." @default.
- W2105871194 created "2016-06-24" @default.
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- W2105871194 date "2014-08-26" @default.
- W2105871194 modified "2023-10-17" @default.
- W2105871194 title "PNA-Encoded Synthesis (PES) of a 10 000-Member Hetero-Glycoconjugate Library and Microarray Analysis of Diverse Lectins" @default.
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- W2105871194 doi "https://doi.org/10.1002/cbic.201402280" @default.
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