FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105889471> ?p ?o ?g. }

• W2105889471 endingPage "519" @default.
• W2105889471 startingPage "507" @default.
• W2105889471 abstract "4-{(R)-(3-Aminophenyl)[4-(4-fluorobenzyl)-piperazin-1-yl]methyl}-N,N-diethylbenzamide (AZD2327) is a highly potent and selective agonist of the δ-opioid receptor. AZD2327 and N-deethylated AZD2327 (M1) are substrates of cytochrome P450 3A (CYP3A4) and comprise a complex multiple inhibitory system that causes competitive and time-dependent inhibition of CYP3A4. The aim of the current work was to develop a physiologically based pharmacokinetic (PBPK) model to predict quantitatively the magnitude of CYP3A4 mediated drug-drug interaction with midazolam as the substrate. Integrating in silico, in vitro and in vivo PK data, a PBPK model was successfully developed to simulate the clinical accumulation of AZD2327 and its primary metabolite. The inhibition of CYP3A4 by AZD2327, using midazolam as a probe drug, was reasonably predicted. The predicted maximum concentration (Cmax) and area under the concentration-time curve (AUC) for midazolam were increased by 1.75 and 2.45-fold, respectively, after multiple dosing of AZD2327, indicating no or low risk for clinically relevant drug-drug interactions (DDI). These results are in agreement with those obtained in a clinical trial with a 1.4 and 1.5-fold increase in Cmax and AUC of midazolam, respectively. In conclusion, this model simulated DDI with less than a two-fold error, indicating that complex clinical DDI associated with multiple mechanisms, pathways and inhibitors (parent and metabolite) can be predicted using a well-developed PBPK model." @default.
• W2105889471 created "2016-06-24" @default.
• W2105889471 creator A5021035771 @default.
• W2105889471 creator A5029676604 @default.
• W2105889471 creator A5029689967 @default.
• W2105889471 creator A5039980957 @default.
• W2105889471 date "2015-07-27" @default.
• W2105889471 modified "2023-09-26" @default.
• W2105889471 title "Physiologically based pharmacokinetic modeling to predict complex drug-drug interactions: a case study of AZD2327 and its metabolite, competitive and time-dependent CYP3A inhibitors" @default.
• W2105889471 cites W1505495051 @default.
• W2105889471 cites W1916407220 @default.
• W2105889471 cites W1967519053 @default.
• W2105889471 cites W1968142899 @default.
• W2105889471 cites W1972179417 @default.
• W2105889471 cites W1991072079 @default.
• W2105889471 cites W1992885095 @default.
• W2105889471 cites W1997264225 @default.
• W2105889471 cites W2004696557 @default.
• W2105889471 cites W2008754951 @default.
• W2105889471 cites W2016245021 @default.
• W2105889471 cites W2018005744 @default.
• W2105889471 cites W2029799717 @default.
• W2105889471 cites W2034606094 @default.
• W2105889471 cites W2072044044 @default.
• W2105889471 cites W2072668343 @default.
• W2105889471 cites W2072807884 @default.
• W2105889471 cites W2072916781 @default.
• W2105889471 cites W2075715526 @default.
• W2105889471 cites W2085937704 @default.
• W2105889471 cites W2105664653 @default.
• W2105889471 cites W2113830209 @default.
• W2105889471 cites W2117272632 @default.
• W2105889471 cites W2149070637 @default.
• W2105889471 doi "https://doi.org/10.1002/bdd.1962" @default.
• W2105889471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26081137" @default.
• W2105889471 hasPublicationYear "2015" @default.
• W2105889471 type Work @default.
• W2105889471 sameAs 2105889471 @default.
• W2105889471 citedByCount "7" @default.
• W2105889471 countsByYear W21058894712016 @default.
• W2105889471 countsByYear W21058894712017 @default.
• W2105889471 countsByYear W21058894712018 @default.
• W2105889471 countsByYear W21058894712021 @default.
• W2105889471 countsByYear W21058894712022 @default.
• W2105889471 crossrefType "journal-article" @default.
• W2105889471 hasAuthorship W2105889471A5021035771 @default.
• W2105889471 hasAuthorship W2105889471A5029676604 @default.
• W2105889471 hasAuthorship W2105889471A5029689967 @default.
• W2105889471 hasAuthorship W2105889471A5039980957 @default.
• W2105889471 hasConcept C104317684 @default.
• W2105889471 hasConcept C109650736 @default.
• W2105889471 hasConcept C112705442 @default.
• W2105889471 hasConcept C11824378 @default.
• W2105889471 hasConcept C149151106 @default.
• W2105889471 hasConcept C150903083 @default.
• W2105889471 hasConcept C181199279 @default.
• W2105889471 hasConcept C185592680 @default.
• W2105889471 hasConcept C185867374 @default.
• W2105889471 hasConcept C207001950 @default.
• W2105889471 hasConcept C22979827 @default.
• W2105889471 hasConcept C2775905019 @default.
• W2105889471 hasConcept C2776814716 @default.
• W2105889471 hasConcept C2777477808 @default.
• W2105889471 hasConcept C2778000748 @default.
• W2105889471 hasConcept C2780035454 @default.
• W2105889471 hasConcept C2910466267 @default.
• W2105889471 hasConcept C526171541 @default.
• W2105889471 hasConcept C55493867 @default.
• W2105889471 hasConcept C71924100 @default.
• W2105889471 hasConcept C86803240 @default.
• W2105889471 hasConcept C97320921 @default.
• W2105889471 hasConcept C98274493 @default.
• W2105889471 hasConceptScore W2105889471C104317684 @default.
• W2105889471 hasConceptScore W2105889471C109650736 @default.
• W2105889471 hasConceptScore W2105889471C112705442 @default.
• W2105889471 hasConceptScore W2105889471C11824378 @default.
• W2105889471 hasConceptScore W2105889471C149151106 @default.
• W2105889471 hasConceptScore W2105889471C150903083 @default.
• W2105889471 hasConceptScore W2105889471C181199279 @default.
• W2105889471 hasConceptScore W2105889471C185592680 @default.
• W2105889471 hasConceptScore W2105889471C185867374 @default.
• W2105889471 hasConceptScore W2105889471C207001950 @default.
• W2105889471 hasConceptScore W2105889471C22979827 @default.
• W2105889471 hasConceptScore W2105889471C2775905019 @default.
• W2105889471 hasConceptScore W2105889471C2776814716 @default.
• W2105889471 hasConceptScore W2105889471C2777477808 @default.
• W2105889471 hasConceptScore W2105889471C2778000748 @default.
• W2105889471 hasConceptScore W2105889471C2780035454 @default.
• W2105889471 hasConceptScore W2105889471C2910466267 @default.
• W2105889471 hasConceptScore W2105889471C526171541 @default.
• W2105889471 hasConceptScore W2105889471C55493867 @default.
• W2105889471 hasConceptScore W2105889471C71924100 @default.
• W2105889471 hasConceptScore W2105889471C86803240 @default.
• W2105889471 hasConceptScore W2105889471C97320921 @default.
• W2105889471 hasConceptScore W2105889471C98274493 @default.
• W2105889471 hasIssue "8" @default.
• W2105889471 hasLocation W21058894711 @default.
• W2105889471 hasLocation W21058894712 @default.

• next