FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105893463> ?p ?o ?g. }

• W2105893463 endingPage "886" @default.
• W2105893463 startingPage "871" @default.
• W2105893463 abstract "An accumulation of misfolded proteins can trigger a cellular survival response in the endoplasmic reticulum (ER). In this study, we found that ER stress-associated gene signatures were highly expressed in rheumatoid arthritis (RA) synoviums and synovial cells. Proinflammatory cytokines, such as TNF and IL-1β, increased the expression of GRP78/BiP, a representative ER chaperone, in RA synoviocytes. RA synoviocytes expressed higher levels of GRP78 than osteoarthritis (OA) synoviocytes when stimulated by thapsigargin or proinflammatory cytokines. Down-regulation of Grp78 transcripts increased the apoptosis of RA synoviocytes while abolishing TNF- or TGF-β-induced synoviocyte proliferation and cyclin D1 up-regulation. Conversely, overexpression of the Grp78 gene prevented synoviocyte apoptosis. Moreover, Grp78 small interfering RNA inhibited VEGF(165)-induced angiogenesis in vitro and also significantly impeded synoviocyte proliferation and angiogenesis in Matrigel implants engrafted into immunodeficient mice. Additionally, repeated intraarticular injections of BiP-inducible factor X, a selective GRP78 inducer, increased synoviocyte proliferation and angiogenesis in the joints of mice with experimental OA. In contrast, mice with Grp78 haploinsufficiency exhibited the suppression of experimentally induced arthritis and developed a limited degree of synovial proliferation and angiogenesis. In summary, this study shows that the ER chaperone GRP78 is crucial for synoviocyte proliferation and angiogenesis, the pathological hallmark of RA." @default.
• W2105893463 created "2016-06-24" @default.
• W2105893463 creator A5014699929 @default.
• W2105893463 creator A5025440878 @default.
• W2105893463 creator A5027374744 @default.
• W2105893463 creator A5042328864 @default.
• W2105893463 creator A5047879387 @default.
• W2105893463 creator A5047895958 @default.
• W2105893463 creator A5052841252 @default.
• W2105893463 creator A5057065367 @default.
• W2105893463 creator A5064181667 @default.
• W2105893463 creator A5068337938 @default.
• W2105893463 creator A5078891698 @default.
• W2105893463 creator A5081427251 @default.
• W2105893463 creator A5082529000 @default.
• W2105893463 date "2012-03-19" @default.
• W2105893463 modified "2023-10-18" @default.
• W2105893463 title "A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis" @default.
• W2105893463 cites W1497659049 @default.
• W2105893463 cites W1501899407 @default.
• W2105893463 cites W1587065262 @default.
• W2105893463 cites W1805389064 @default.
• W2105893463 cites W1820973630 @default.
• W2105893463 cites W1970090264 @default.
• W2105893463 cites W1972849225 @default.
• W2105893463 cites W1978999653 @default.
• W2105893463 cites W1982011044 @default.
• W2105893463 cites W1984282191 @default.
• W2105893463 cites W1988285559 @default.
• W2105893463 cites W1989347991 @default.
• W2105893463 cites W2000237287 @default.
• W2105893463 cites W2000313088 @default.
• W2105893463 cites W2007922054 @default.
• W2105893463 cites W2015705446 @default.
• W2105893463 cites W2027077104 @default.
• W2105893463 cites W2035623537 @default.
• W2105893463 cites W2043718270 @default.
• W2105893463 cites W2049876394 @default.
• W2105893463 cites W2057325749 @default.
• W2105893463 cites W2059979102 @default.
• W2105893463 cites W2060311903 @default.
• W2105893463 cites W2062918974 @default.
• W2105893463 cites W2066538173 @default.
• W2105893463 cites W2068511150 @default.
• W2105893463 cites W2072610101 @default.
• W2105893463 cites W2084276537 @default.
• W2105893463 cites W2091341678 @default.
• W2105893463 cites W2093310356 @default.
• W2105893463 cites W2094036848 @default.
• W2105893463 cites W2097868610 @default.
• W2105893463 cites W2102025854 @default.
• W2105893463 cites W2110212786 @default.
• W2105893463 cites W2110524342 @default.
• W2105893463 cites W2120865735 @default.
• W2105893463 cites W2123840402 @default.
• W2105893463 cites W2130092335 @default.
• W2105893463 cites W2130633466 @default.
• W2105893463 cites W2132988886 @default.
• W2105893463 cites W2137662702 @default.
• W2105893463 cites W2142282255 @default.
• W2105893463 cites W2144972431 @default.
• W2105893463 cites W2147950253 @default.
• W2105893463 cites W2149103649 @default.
• W2105893463 cites W2152348310 @default.
• W2105893463 cites W2163411496 @default.
• W2105893463 cites W4236183098 @default.
• W2105893463 cites W4250374989 @default.
• W2105893463 doi "https://doi.org/10.1084/jem.20111783" @default.
• W2105893463 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3328363" @default.
• W2105893463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22430489" @default.
• W2105893463 hasPublicationYear "2012" @default.
• W2105893463 type Work @default.
• W2105893463 sameAs 2105893463 @default.
• W2105893463 citedByCount "124" @default.
• W2105893463 countsByYear W21058934632012 @default.
• W2105893463 countsByYear W21058934632013 @default.
• W2105893463 countsByYear W21058934632014 @default.
• W2105893463 countsByYear W21058934632015 @default.
• W2105893463 countsByYear W21058934632016 @default.
• W2105893463 countsByYear W21058934632017 @default.
• W2105893463 countsByYear W21058934632018 @default.
• W2105893463 countsByYear W21058934632019 @default.
• W2105893463 countsByYear W21058934632020 @default.
• W2105893463 countsByYear W21058934632021 @default.
• W2105893463 countsByYear W21058934632022 @default.
• W2105893463 countsByYear W21058934632023 @default.
• W2105893463 crossrefType "journal-article" @default.
• W2105893463 hasAuthorship W2105893463A5014699929 @default.
• W2105893463 hasAuthorship W2105893463A5025440878 @default.
• W2105893463 hasAuthorship W2105893463A5027374744 @default.
• W2105893463 hasAuthorship W2105893463A5042328864 @default.
• W2105893463 hasAuthorship W2105893463A5047879387 @default.
• W2105893463 hasAuthorship W2105893463A5047895958 @default.
• W2105893463 hasAuthorship W2105893463A5052841252 @default.
• W2105893463 hasAuthorship W2105893463A5057065367 @default.
• W2105893463 hasAuthorship W2105893463A5064181667 @default.
• W2105893463 hasAuthorship W2105893463A5068337938 @default.
• W2105893463 hasAuthorship W2105893463A5078891698 @default.

• next