FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105909402> ?p ?o ?g. }

• W2105909402 endingPage "25" @default.
• W2105909402 startingPage "17" @default.
• W2105909402 abstract "Bacterial cell division occurs through the formation of a protein ring (division ring) at the site of division, with FtsZ being its main component in most bacteria. FtsZ is the prokaryotic ortholog of eukaryotic tubulin; it shares GTPase activity properties and the ability to polymerize in vitro. To study the mechanism of action of FtsZ, we used molecular dynamics simulations of the behavior of the FtsZ dimer in the presence of GTP–Mg2+ and monovalent cations. The presence of a K+ ion at the GTP binding site allows the positioning of one water molecule that interacts with catalytic residues Asp235 and Asp238, which are also involved in the coordination sphere of K+. This arrangement might favor dimer stability and GTP hydrolysis. Contrary to this, Na+ destabilizes the dimer and does not allow the positioning of the catalytic water molecule. Protonation of the GTP gamma-phosphate, simulating low pH, excludes both monovalent cations and the catalytic water molecule from the GTP binding site and stabilizes the dimer. These molecular dynamics predictions were contrasted experimentally by analyzing the GTPase and polymerization activities of purified Methanococcus jannaschii and Escherichia coli FtsZ proteins in vitro." @default.
• W2105909402 created "2016-06-24" @default.
• W2105909402 creator A5006627107 @default.
• W2105909402 creator A5017996223 @default.
• W2105909402 creator A5024970618 @default.
• W2105909402 creator A5061201501 @default.
• W2105909402 creator A5084350139 @default.
• W2105909402 creator A5088907700 @default.
• W2105909402 date "2009-07-01" @default.
• W2105909402 modified "2023-09-27" @default.
• W2105909402 title "Structural and Functional Model for Ionic (K+/Na+) and pH Dependence of GTPase Activity and Polymerization of FtsZ, the Prokaryotic Ortholog of Tubulin" @default.
• W2105909402 cites W1981242878 @default.
• W2105909402 cites W2004547176 @default.
• W2105909402 cites W2030590806 @default.
• W2105909402 cites W2032459185 @default.
• W2105909402 cites W2035935654 @default.
• W2105909402 cites W2036777468 @default.
• W2105909402 cites W2040676542 @default.
• W2105909402 cites W2046350665 @default.
• W2105909402 cites W2050339362 @default.
• W2105909402 cites W2051230818 @default.
• W2105909402 cites W2052066505 @default.
• W2105909402 cites W2060221814 @default.
• W2105909402 cites W2061884720 @default.
• W2105909402 cites W2072256706 @default.
• W2105909402 cites W2101063809 @default.
• W2105909402 cites W2108596213 @default.
• W2105909402 cites W2118233996 @default.
• W2105909402 cites W2121292998 @default.
• W2105909402 cites W2123989172 @default.
• W2105909402 cites W2126055327 @default.
• W2105909402 cites W2129892556 @default.
• W2105909402 cites W2143047507 @default.
• W2105909402 cites W2148029747 @default.
• W2105909402 cites W2151801929 @default.
• W2105909402 cites W2154149279 @default.
• W2105909402 cites W2156627055 @default.
• W2105909402 cites W2231614804 @default.
• W2105909402 doi "https://doi.org/10.1016/j.jmb.2009.05.018" @default.
• W2105909402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19447111" @default.
• W2105909402 hasPublicationYear "2009" @default.
• W2105909402 type Work @default.
• W2105909402 sameAs 2105909402 @default.
• W2105909402 citedByCount "41" @default.
• W2105909402 countsByYear W21059094022012 @default.
• W2105909402 countsByYear W21059094022013 @default.
• W2105909402 countsByYear W21059094022014 @default.
• W2105909402 countsByYear W21059094022015 @default.
• W2105909402 countsByYear W21059094022017 @default.
• W2105909402 countsByYear W21059094022018 @default.
• W2105909402 countsByYear W21059094022019 @default.
• W2105909402 countsByYear W21059094022020 @default.
• W2105909402 countsByYear W21059094022021 @default.
• W2105909402 countsByYear W21059094022022 @default.
• W2105909402 crossrefType "journal-article" @default.
• W2105909402 hasAuthorship W2105909402A5006627107 @default.
• W2105909402 hasAuthorship W2105909402A5017996223 @default.
• W2105909402 hasAuthorship W2105909402A5024970618 @default.
• W2105909402 hasAuthorship W2105909402A5061201501 @default.
• W2105909402 hasAuthorship W2105909402A5084350139 @default.
• W2105909402 hasAuthorship W2105909402A5088907700 @default.
• W2105909402 hasBestOaLocation W21059094022 @default.
• W2105909402 hasConcept C104317684 @default.
• W2105909402 hasConcept C118716 @default.
• W2105909402 hasConcept C12554922 @default.
• W2105909402 hasConcept C1491633281 @default.
• W2105909402 hasConcept C178790620 @default.
• W2105909402 hasConcept C181199279 @default.
• W2105909402 hasConcept C185592680 @default.
• W2105909402 hasConcept C20418707 @default.
• W2105909402 hasConcept C207332259 @default.
• W2105909402 hasConcept C2776237524 @default.
• W2105909402 hasConcept C2776878370 @default.
• W2105909402 hasConcept C2779546866 @default.
• W2105909402 hasConcept C547475151 @default.
• W2105909402 hasConcept C55493867 @default.
• W2105909402 hasConcept C71240020 @default.
• W2105909402 hasConcept C84425145 @default.
• W2105909402 hasConcept C85813293 @default.
• W2105909402 hasConcept C86803240 @default.
• W2105909402 hasConcept C95444343 @default.
• W2105909402 hasConceptScore W2105909402C104317684 @default.
• W2105909402 hasConceptScore W2105909402C118716 @default.
• W2105909402 hasConceptScore W2105909402C12554922 @default.
• W2105909402 hasConceptScore W2105909402C1491633281 @default.
• W2105909402 hasConceptScore W2105909402C178790620 @default.
• W2105909402 hasConceptScore W2105909402C181199279 @default.
• W2105909402 hasConceptScore W2105909402C185592680 @default.
• W2105909402 hasConceptScore W2105909402C20418707 @default.
• W2105909402 hasConceptScore W2105909402C207332259 @default.
• W2105909402 hasConceptScore W2105909402C2776237524 @default.
• W2105909402 hasConceptScore W2105909402C2776878370 @default.
• W2105909402 hasConceptScore W2105909402C2779546866 @default.
• W2105909402 hasConceptScore W2105909402C547475151 @default.
• W2105909402 hasConceptScore W2105909402C55493867 @default.
• W2105909402 hasConceptScore W2105909402C71240020 @default.
• W2105909402 hasConceptScore W2105909402C84425145 @default.
• W2105909402 hasConceptScore W2105909402C85813293 @default.

• next