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• W2105954474 abstract "Identification of a distinct secretion pattern of adipocytokines from creeping fat in Crohn’s disease and from mesenteric adipose tissue in chronic inflammatory bowel diseases (IBD) or mesenteric diseases can be considered as work in progress. Characterisation of visceral adipose tissue by its highly active secretory products may lead to the discovery of specific discrimination and activity markers in IBD and may provide future targets for drug therapy. In addition, the cellular compartment of macrophages residing within the mesenteric adipose tissue is becoming recognised as bearing pathophysiological relevance.The connective and adipose tissue changes observed in patients with Crohn’s disease (CD) have received only little attention from pathologists, although fat hypertrophy, fat wrapping (fat creeping upon the bowel), and creeping fat have long been recognised by surgeons as a phenomenon suitable for delineating the extent of active disease. Dr Burril B Crohn himself, who gave his name to this chronic inflammatory bowel disease, initially described the changes in the appearance of the mesenteric adipose tissue as a characteristic symptom of the disease.1 Sheehan and colleagues2 and others3 defined fat wrapping as present if more than 50% of the intestinal surface is covered by adipose tissue. Fat encroachment of the antimesenteric surface of the bowel displays a characteristic feature of CD, leading to complete enveloping of the antimesenteric surface and obliteration of the bowel-mesentery angle.3To date, the pathophysiology of creeping fat has been investigated only sporadically2–5 and it seems to have fallen into oblivion.6Adipose tissue has long been regarded as a passive type of connective tissue that stores energy as triglycerides and releases energy as free fatty acids. However, due to the wide variety of hormones, proteins, peptides, complement factors, cytokines, enzymes, and receptors expressed in and secreted by adipocytes, the total adipose …" @default.
• W2105954474 created "2016-06-24" @default.
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• W2105954474 date "2005-06-01" @default.
• W2105954474 modified "2023-09-30" @default.
• W2105954474 title "Creeping fat in Crohn's disease: travelling in a creeper lane of research?" @default.
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• W2105954474 doi "https://doi.org/10.1136/gut.2004.061531" @default.
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