Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105957574> ?p ?o ?g. }
- W2105957574 endingPage "810" @default.
- W2105957574 startingPage "799" @default.
- W2105957574 abstract "ABSTRACT The de novo formation of multilayered spore walls inside a diploid mother cell is a major landmark of sporulation in the yeast Saccharomyces cerevisiae . Synthesis of the dityrosine-rich outer spore wall takes place toward the end of this process. Bisformyl dityrosine, the major building block of the spore surface, is synthesized in a multistep process in the cytoplasm of the prospores, transported to the maturing wall, and polymerized into a highly cross-linked macromolecule on the spore surface. Here we present evidence that the sporulation-specific protein Dtr1p (encoded by YBR180w ) plays an important role in spore wall synthesis by facilitating the translocation of bisformyl dityrosine through the prospore membrane. DTR1 was identified in a genome-wide screen for spore wall mutants. The null mutant accumulates unusually large amounts of bisformyl dityrosine in the cytoplasm and fails to efficiently incorporate this precursor into the spore surface. As a result, many mutant spores have aberrant surface structures. Dtr1p, a member of the poorly characterized DHA12 (drug:H + antiporter with 12 predicted membrane spans) family, is localized in the prospore membrane throughout spore maturation. Transport by Dtr1p may not be restricted to its natural substrate, bisformyl dityrosine. When expressed in vegetative cells, Dtr1p renders these cells slightly more resistant against unrelated toxic compounds, such as antimalarial drugs and food-grade organic acid preservatives. Dtr1p is the first multidrug resistance protein of the major facilitator superfamily with an assigned physiological role in the yeast cell." @default.
- W2105957574 created "2016-06-24" @default.
- W2105957574 creator A5000072835 @default.
- W2105957574 creator A5011114213 @default.
- W2105957574 creator A5041596552 @default.
- W2105957574 creator A5056030772 @default.
- W2105957574 creator A5086484120 @default.
- W2105957574 creator A5088615436 @default.
- W2105957574 date "2002-10-01" @default.
- W2105957574 modified "2023-09-27" @default.
- W2105957574 title "Dtr1p, a Multidrug Resistance Transporter of the Major Facilitator Superfamily, Plays an Essential Role in Spore Wall Maturation in <i>Saccharomyces cerevisiae</i>" @default.
- W2105957574 cites W131157789 @default.
- W2105957574 cites W1507436219 @default.
- W2105957574 cites W1517816201 @default.
- W2105957574 cites W1583351416 @default.
- W2105957574 cites W1896499191 @default.
- W2105957574 cites W1916002325 @default.
- W2105957574 cites W1963490149 @default.
- W2105957574 cites W1967390330 @default.
- W2105957574 cites W1971710717 @default.
- W2105957574 cites W1974054235 @default.
- W2105957574 cites W1987433777 @default.
- W2105957574 cites W1989686253 @default.
- W2105957574 cites W1991760918 @default.
- W2105957574 cites W1992389633 @default.
- W2105957574 cites W1994336718 @default.
- W2105957574 cites W1998153199 @default.
- W2105957574 cites W1999375557 @default.
- W2105957574 cites W2006472880 @default.
- W2105957574 cites W2013180063 @default.
- W2105957574 cites W2018215453 @default.
- W2105957574 cites W2032758517 @default.
- W2105957574 cites W2033049942 @default.
- W2105957574 cites W2037240543 @default.
- W2105957574 cites W2044061221 @default.
- W2105957574 cites W2048684608 @default.
- W2105957574 cites W2051287358 @default.
- W2105957574 cites W2057902721 @default.
- W2105957574 cites W2063036465 @default.
- W2105957574 cites W2073707814 @default.
- W2105957574 cites W2075240236 @default.
- W2105957574 cites W2082386832 @default.
- W2105957574 cites W2091244534 @default.
- W2105957574 cites W2101447091 @default.
- W2105957574 cites W2106252547 @default.
- W2105957574 cites W2113543622 @default.
- W2105957574 cites W2122854619 @default.
- W2105957574 cites W2124813365 @default.
- W2105957574 cites W2128653641 @default.
- W2105957574 cites W2135951244 @default.
- W2105957574 cites W2140948740 @default.
- W2105957574 cites W2154066368 @default.
- W2105957574 cites W2161326331 @default.
- W2105957574 cites W2165802724 @default.
- W2105957574 cites W2169575091 @default.
- W2105957574 cites W4233242819 @default.
- W2105957574 cites W4243368782 @default.
- W2105957574 doi "https://doi.org/10.1128/ec.1.5.799-810.2002" @default.
- W2105957574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/126748" @default.
- W2105957574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12455697" @default.
- W2105957574 hasPublicationYear "2002" @default.
- W2105957574 type Work @default.
- W2105957574 sameAs 2105957574 @default.
- W2105957574 citedByCount "72" @default.
- W2105957574 countsByYear W21059575742012 @default.
- W2105957574 countsByYear W21059575742013 @default.
- W2105957574 countsByYear W21059575742014 @default.
- W2105957574 countsByYear W21059575742015 @default.
- W2105957574 countsByYear W21059575742016 @default.
- W2105957574 countsByYear W21059575742017 @default.
- W2105957574 countsByYear W21059575742019 @default.
- W2105957574 countsByYear W21059575742020 @default.
- W2105957574 countsByYear W21059575742021 @default.
- W2105957574 countsByYear W21059575742022 @default.
- W2105957574 countsByYear W21059575742023 @default.
- W2105957574 crossrefType "journal-article" @default.
- W2105957574 hasAuthorship W2105957574A5000072835 @default.
- W2105957574 hasAuthorship W2105957574A5011114213 @default.
- W2105957574 hasAuthorship W2105957574A5041596552 @default.
- W2105957574 hasAuthorship W2105957574A5056030772 @default.
- W2105957574 hasAuthorship W2105957574A5086484120 @default.
- W2105957574 hasAuthorship W2105957574A5088615436 @default.
- W2105957574 hasBestOaLocation W21059575742 @default.
- W2105957574 hasConcept C104317684 @default.
- W2105957574 hasConcept C125235067 @default.
- W2105957574 hasConcept C143065580 @default.
- W2105957574 hasConcept C174618031 @default.
- W2105957574 hasConcept C190062978 @default.
- W2105957574 hasConcept C2777576037 @default.
- W2105957574 hasConcept C2779222958 @default.
- W2105957574 hasConcept C41625074 @default.
- W2105957574 hasConcept C55493867 @default.
- W2105957574 hasConcept C57181701 @default.
- W2105957574 hasConcept C62465871 @default.
- W2105957574 hasConcept C86803240 @default.
- W2105957574 hasConcept C89423630 @default.
- W2105957574 hasConcept C95444343 @default.
- W2105957574 hasConceptScore W2105957574C104317684 @default.