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- W2105963284 abstract "Neuromyelitis optica (NMO) or Devic’s disease is a severe demyelinating disease of the CNS affecting primarily optic nerves and spinal cord, secondary to a B-cell- and Ab-mediated autoimmune condition.1 This concept was recently bolstered by the demonstration of disease-specific NMO-Abs,2 and the apparent beneficial effect of B-cell depletion.3 Here, we used a protein microarray approach to profile the Ag reactivity of serum IgG from NMO patients.Sera from five patients fulfilling NMO criteria (Cases 2 through 6 described elsewhere3) and five healthy controls were tested. Because patients experienced relapses and progressive clinical impairment despite therapy, they received rituximab as an off-label, innovative treatment.3A 20-year-old woman with NMO associated with a high relapse rate (19 relapses within the last 6 years) was blind, wheelchair bound, and had a mid-thoracic sensory level and urinary and stool incontinence. Following treatment with rituximab, she experienced improved strength and sensation in her legs. She had an attack of myelitis approximately 1 month after her first course of rituximab from which she recovered spontaneously without additional treatment. At 1 year follow up, her vision remained impaired but she recovered full strength in her legs, normal …" @default.
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- W2105963284 date "2006-07-10" @default.
- W2105963284 modified "2023-09-27" @default.
- W2105963284 title "Identification of new serum autoantibodies in neuromyelitis optica using protein microarrays" @default.
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- W2105963284 doi "https://doi.org/10.1212/01.wnl.0000223346.09426.34" @default.
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