FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105977990> ?p ?o ?g. }

• W2105977990 endingPage "7263" @default.
• W2105977990 startingPage "7258" @default.
• W2105977990 abstract "Pyrazinamide (PZA) is a first-line tuberculosis drug that inhibits the growth of Mycobacterium tuberculosis via an as yet undefined mechanism. An M. tuberculosis laboratory strain that was auxotrophic for pantothenate was found to be insensitive to PZA and to the active form, pyrazinoic acid (POA). To determine whether this phenotype was strain or condition specific, the effect of pantothenate supplementation on PZA activity was assessed using prototrophic strains of M. tuberculosis. It was found that pantothenate and other β-alanine-containing metabolites abolished PZA and POA susceptibility, suggesting that POA might selectively target pantothenate synthesis. However, when the pantothenate-auxotrophic strain was cultivated using a subantagonistic concentration of pantetheine in lieu of pantothenate, susceptibility to PZA and POA was restored. In addition, we found that β-alanine could not antagonize PZA and POA activity against the pantothenate-auxotrophic strain, indicating that the antagonism is specific to pantothenate. Moreover, pantothenate-mediated antagonism was observed for structurally related compounds, including n-propyl pyrazinoate, 5-chloropyrazinamide, and nicotinamide, but not for nicotinic acid or isoniazid. Taken together, these data demonstrate that while pantothenate can interfere with the action of PZA, pantothenate synthesis is not directly targeted by PZA. Our findings suggest that targeting of pantothenate synthesis has the potential to enhance PZA efficacy and possibly to restore PZA susceptibility in isolates with panD-linked resistance." @default.
• W2105977990 created "2016-06-24" @default.
• W2105977990 creator A5024921031 @default.
• W2105977990 creator A5031581114 @default.
• W2105977990 creator A5051111256 @default.
• W2105977990 creator A5073957782 @default.
• W2105977990 date "2014-12-01" @default.
• W2105977990 modified "2023-10-03" @default.
• W2105977990 title "Pantothenate and Pantetheine Antagonize the Antitubercular Activity of Pyrazinamide" @default.
• W2105977990 cites W114727475 @default.
• W2105977990 cites W1541368704 @default.
• W2105977990 cites W1591852988 @default.
• W2105977990 cites W1923394711 @default.
• W2105977990 cites W1974536245 @default.
• W2105977990 cites W1975610050 @default.
• W2105977990 cites W1978977963 @default.
• W2105977990 cites W1998211794 @default.
• W2105977990 cites W2008086616 @default.
• W2105977990 cites W2008232376 @default.
• W2105977990 cites W2017227464 @default.
• W2105977990 cites W2039394359 @default.
• W2105977990 cites W2039449039 @default.
• W2105977990 cites W2050026866 @default.
• W2105977990 cites W2065130119 @default.
• W2105977990 cites W2075505441 @default.
• W2105977990 cites W2079354784 @default.
• W2105977990 cites W2096742175 @default.
• W2105977990 cites W2096775679 @default.
• W2105977990 cites W2098335911 @default.
• W2105977990 cites W2109719233 @default.
• W2105977990 cites W2128020518 @default.
• W2105977990 cites W2138751689 @default.
• W2105977990 cites W2140578600 @default.
• W2105977990 cites W2140797812 @default.
• W2105977990 cites W2147480071 @default.
• W2105977990 cites W2155742575 @default.
• W2105977990 cites W2158023121 @default.
• W2105977990 cites W2166215411 @default.
• W2105977990 cites W2167190401 @default.
• W2105977990 cites W2168066272 @default.
• W2105977990 doi "https://doi.org/10.1128/aac.04028-14" @default.
• W2105977990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4249577" @default.
• W2105977990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25246400" @default.
• W2105977990 hasPublicationYear "2014" @default.
• W2105977990 type Work @default.
• W2105977990 sameAs 2105977990 @default.
• W2105977990 citedByCount "59" @default.
• W2105977990 countsByYear W21059779902015 @default.
• W2105977990 countsByYear W21059779902016 @default.
• W2105977990 countsByYear W21059779902017 @default.
• W2105977990 countsByYear W21059779902018 @default.
• W2105977990 countsByYear W21059779902019 @default.
• W2105977990 countsByYear W21059779902020 @default.
• W2105977990 countsByYear W21059779902021 @default.
• W2105977990 countsByYear W21059779902022 @default.
• W2105977990 countsByYear W21059779902023 @default.
• W2105977990 crossrefType "journal-article" @default.
• W2105977990 hasAuthorship W2105977990A5024921031 @default.
• W2105977990 hasAuthorship W2105977990A5031581114 @default.
• W2105977990 hasAuthorship W2105977990A5051111256 @default.
• W2105977990 hasAuthorship W2105977990A5073957782 @default.
• W2105977990 hasBestOaLocation W21059779901 @default.
• W2105977990 hasConcept C104317684 @default.
• W2105977990 hasConcept C142724271 @default.
• W2105977990 hasConcept C143065580 @default.
• W2105977990 hasConcept C170493617 @default.
• W2105977990 hasConcept C20950039 @default.
• W2105977990 hasConcept C2776155809 @default.
• W2105977990 hasConcept C2776967927 @default.
• W2105977990 hasConcept C2777383412 @default.
• W2105977990 hasConcept C2777975735 @default.
• W2105977990 hasConcept C2778607973 @default.
• W2105977990 hasConcept C2780420027 @default.
• W2105977990 hasConcept C2780459521 @default.
• W2105977990 hasConcept C2781069245 @default.
• W2105977990 hasConcept C501593827 @default.
• W2105977990 hasConcept C55493867 @default.
• W2105977990 hasConcept C71924100 @default.
• W2105977990 hasConcept C86803240 @default.
• W2105977990 hasConcept C89423630 @default.
• W2105977990 hasConcept C98274493 @default.
• W2105977990 hasConceptScore W2105977990C104317684 @default.
• W2105977990 hasConceptScore W2105977990C142724271 @default.
• W2105977990 hasConceptScore W2105977990C143065580 @default.
• W2105977990 hasConceptScore W2105977990C170493617 @default.
• W2105977990 hasConceptScore W2105977990C20950039 @default.
• W2105977990 hasConceptScore W2105977990C2776155809 @default.
• W2105977990 hasConceptScore W2105977990C2776967927 @default.
• W2105977990 hasConceptScore W2105977990C2777383412 @default.
• W2105977990 hasConceptScore W2105977990C2777975735 @default.
• W2105977990 hasConceptScore W2105977990C2778607973 @default.
• W2105977990 hasConceptScore W2105977990C2780420027 @default.
• W2105977990 hasConceptScore W2105977990C2780459521 @default.
• W2105977990 hasConceptScore W2105977990C2781069245 @default.
• W2105977990 hasConceptScore W2105977990C501593827 @default.
• W2105977990 hasConceptScore W2105977990C55493867 @default.
• W2105977990 hasConceptScore W2105977990C71924100 @default.
• W2105977990 hasConceptScore W2105977990C86803240 @default.

• next