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- W2105981572 abstract "Individual genetic variation accounts for some of the variability in response to drugs used routinely in clinical psychiatry. Psychopharmacogenetics focuses on how polymorphisms in genes affecting the mechanism of action of a drug's effect and/or metabolism (both peripheral and central) can influence an individual's clinical response to the drug, in terms of both therapeutic efficacy and adverse effects. Pharmacogenetics promises to be of substantial help in the field of psychiatric pharmacotherapy, but before research findings can be applied to clinical practice, ethical and methodological problems have to be addressed and overcome. This review summarises the most robust findings in the field and outlines how psychopharmacogenetic studies could lead to treatment individualisation." @default.
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- W2105981572 date "2004-11-01" @default.
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- W2105981572 title "Clinical relevance of discoveries in psychopharmacogenetics1" @default.
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- W2105981572 doi "https://doi.org/10.1192/apt.10.6.455" @default.
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