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• W2106012307 abstract "T follicular helper (Tfh) cells represent a Th subset engaged in the help of B-cell responses in germinal centers (GCs). Tfh cells abundantly express the transcription repressor B-cell lymphoma 6 (Bcl6), a factor that is necessary and sufficient for their development in vivo. Whether Tfh or Tfh-committed cells are involved in the help of B cells outside GCs remains unclear, particularly in humans. In this study, we identified a previously undefined BCL6-expressing CD4(+) T-cell subset in human tonsils. This subset expressed IL-7 receptor and chemokine receptor 5 (CXCR5) and inducible costimulator (ICOS) at low levels (CXCR5(lo)ICOS(lo)), and it was found exclusively outside GCs. CXCR5(lo)ICOS(lo) CD4(+) T cells secreted larger amounts of IL-21 and IL-10 than CXCR5(hi)ICOS(hi) GC-Tfh cells upon activation, and they induced proliferation and differentiation of naïve B cells into Ig-producing cells more efficiently than GC-Tfh cells. However, this subset lacked the capacity to help GC-B cells because of the induction of apoptosis of GC-B cells through the FAS/FAS-ligand interaction. CXCR5(lo)ICOS(lo) CD4(+) T cells expressed equivalent amounts of BCL6 transcript with CXCR5(hi)ICOS(hi) GC-Tfh cells, but they expressed less Bcl6 protein. Collectively, our study indicates that CXCR5(lo)ICOS(lo) CD4(+) T cells in human tonsils represent Tfh lineage-committed cells that provide help to naïve and memory B cells outside GCs." @default.
• W2106012307 created "2016-06-24" @default.
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• W2106012307 creator A5047019761 @default.
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• W2106012307 date "2011-08-01" @default.
• W2106012307 modified "2023-09-29" @default.
• W2106012307 title "Human tonsil <i>B</i> - <i>cell lymphoma 6</i> ( <i>BCL6</i> )-expressing CD4 ⁺ T-cell subset specialized for B-cell help outside germinal centers" @default.
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• W2106012307 doi "https://doi.org/10.1073/pnas.1100898108" @default.
• W2106012307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3158181" @default.
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