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• W2106016875 abstract "ABSTRACT The β-lactamases in 154 clinical Mycobacterium tuberculosis strains were studied. Susceptibilities to β-lactam antibiotics, their combination with clavulanate (2:1), and two fluoroquinolones were determined in 24 M. tuberculosis strains susceptible to antimycobacterial drugs and in nine multiresistant strains. All 154 M. tuberculosis isolates showed a single chromosomal β-lactamase pattern (pI 4.9 and 5.1). M. tuberculosis β-lactamase hydrolyzes cefotaxime with a maximum rate of 22.5 ± 2.19 IU/liter (strain 1382). Neither amoxicillin, carbenicillin, cefotaxime, ceftriaxone, nor aztreonam was active alone. Except for aztreonam, β-lactam combinations with clavulanate produced better antimycobacterial activity." @default.
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• W2106016875 date "1998-06-01" @default.
• W2106016875 modified "2023-09-26" @default.
• W2106016875 title "Contribution of β-Lactamases to β-Lactam Susceptibilities of Susceptible and Multidrug-Resistant <i>Mycobacterium tuberculosis</i> Clinical Isolates" @default.
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• W2106016875 doi "https://doi.org/10.1128/aac.42.6.1524" @default.
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