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- W2106040710 abstract "Multiple lines of evidence suggest that a dysfunction in the glutamatergic neurotransmission via the N-methyl- D-aspartate (NMDA) receptors contributes to the pathophysiology of psychiatric diseases including schizophrenia. The potentiation of NMDA receptor function may be a useful approach for the treatment of diseases associated with NMDA receptor hypofunction. One possible strategy is to increase synaptic levels of glycine by blocking the glycine transporter-1 (GlyT-1) in glia cells, since glycine acts as a co-agonist site on the NMDA receptor. In this article, the author reviews the recent important patents on GlyT-1 inhibitors for treatment of schizophrenia and other psychiatric diseases associated with the NMDA receptor hypofunction. Keywords: NMDA receptor, glycine, glycine transporter, glia, cognition, schizophrenia" @default.
- W2106040710 created "2016-06-24" @default.
- W2106040710 creator A5032453300 @default.
- W2106040710 date "2006-01-01" @default.
- W2106040710 modified "2023-09-23" @default.
- W2106040710 title "Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia" @default.
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- W2106040710 doi "https://doi.org/10.2174/157488906775245336" @default.
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