Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106047550> ?p ?o ?g. }
- W2106047550 abstract "Pathogen recognition drives host defense towards viral infections. Specific groups rather than single members of the protein family of pattern recognition receptors (PRRs) such as membrane spanning Toll-like receptors (TLRs) and cytosolic helicases might mediate sensing of replication intermediates of a specific virus species. TLR7 mediates host sensing of retroviruses and could significantly influence retrovirus-specific antibody responses. However, the origin of efficient cell-mediated immunity towards retroviruses is unknown. Double-stranded RNA intermediates produced during retroviral replication are good candidates for immune stimulatory viral products. Thus, we considered TLR3 as primer of cell-mediated immunity against retroviruses in vivo.Infection of mice deficient in TLR3 (TLR3(-/-)) with Friend retrovirus (FV) complex revealed higher viral loads during acute retroviral infection compared to wild type mice. TLR3(-/-) mice exhibited significantly lower expression levels of type I interferons (IFNs) and IFN-stimulated genes like Pkr or Ifi44, as well as reduced numbers of activated myeloid dendritic cells (DCs) (CD86(+) and MHC-II(+)). DCs generated from FV-infected TLR3(-/-) mice were less capable of priming virus-specific CD8(+) T cell proliferation. Moreover, cytotoxicity of natural killer (NK) cells as well as CD8(+) T cells were reduced in vitro and in vivo, respectively, in FV-infected TLR3(-/-) mice.TLR3 mediates antiretroviral cytotoxic NK cell and CD8(+) T cell activity in vivo. Our findings qualify TLR3 as target of immune therapy against retroviral infections." @default.
- W2106047550 created "2016-06-24" @default.
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- W2106047550 date "2014-12-01" @default.
- W2106047550 modified "2023-09-23" @default.
- W2106047550 title "Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3" @default.
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- W2106047550 doi "https://doi.org/10.1186/s12977-014-0126-4" @default.
- W2106047550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4299798" @default.
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