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- W2106057807 endingPage "128" @default.
- W2106057807 startingPage "113" @default.
- W2106057807 abstract "Vascular endothelial growth factor [VEGF] pathway, which plays a key role in angiogenesis, may be blocked by either extracellular interference with VEGF itself (bevacizumab [BEV] or aflibercept), or intracytoplasmic inhibition of VEGF receptor (pazopanib, nintedanib, cediranid, sunitinib and sorafenib). An alternative approach is represented by trebananib, a fusion protein that prevents the interaction of angiopoietin [Ang]-1 and Ang-2 with Tie2 receptor on vascular endothelium. The combination of antiangiogenic agents, especially BEV, and chemotherapy is a rational therapeutic option for primary or recurrent ovarian carcinoma. However, it will be difficult to accept that it represents the new standard treatment, until biological characterization of ovarian carcinoma has not identified subsets of tumors with different responsiveness to BEV. Anti-angiogenesis is an interesting target also for recurrent cervical or endometrial cancer, but nowadays the use of anti-angiogenic agents in these malignancies should be reserved to patients enrolled in clinical trials." @default.
- W2106057807 created "2016-06-24" @default.
- W2106057807 creator A5016006399 @default.
- W2106057807 creator A5073253594 @default.
- W2106057807 creator A5074527671 @default.
- W2106057807 date "2015-10-01" @default.
- W2106057807 modified "2023-10-18" @default.
- W2106057807 title "Antiangiogenic agents in gynecological cancer: State of art and perspectives of clinical research" @default.
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