FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106062955> ?p ?o ?g. }

• W2106062955 endingPage "6168" @default.
• W2106062955 startingPage "6159" @default.
• W2106062955 abstract "Abstract Purpose: Although the mutator phenotype, including genetic and epigenetic alterations of the mismatch repair (MMR) system, seems to be pronounced in familial colorectal cancer, there have been few integrative studies comprising the entire mutator pathway. This study was done to identify the entire mutator pathway determining risk factors in patients with familial colorectal cancer not fulfilling the Amsterdam criteria. Experimental Design: We consecutively recruited 134 colorectal cancer patients with a family history of accompanying cancers. Patients with hereditary nonpolyposis colorectal cancer meeting the Amsterdam criteria, familial adenomatous polyposis, or those receiving preoperative radiotherapy were excluded. Mutator phenotype was assessed by assaying microsatellite instability (MSI) at 24 markers, hMLH1-promoter methylation, mutations at MMR genes (hMLH1, hMSH2, hMSH6, and hPMS2), and immune staining of MMR proteins (hMLH1, hMSH2, hMSH6, hPMS1, and hPMS2). Results: Of the 208 cancers in first-degree and/or second-degree relatives of patients, colorectal and gastric cancers (81%) were most common. Of the 134 proband colorectal cancers, 23 (17%) were MSI in high level, and 32 (24%) were MSI in low level. MMR alterations, including known polymorphism and splicing substitution, were identified in eight patients (6%). Twenty-eight tumors with mutator phenotype were further identified by hMLH1-promoter methylation and/or loss of MMR protein expression. In 51 tumors (38%), mutator phenotype was associated with right-sided colon cancer (P &lt; 0.001) and younger age at onset (P = 0.032), but the number of patients with a mutator phenotype did not differ with respect to inheritance patterns of accompanying cancers, either successive or horizontal transmission (P = 0.815). Familial impact value, which differentially associated the degree of relatives with all accompanying cancers, effectively discriminated MSI in high level from microsatellite stable/MSI in low level tumors. Conclusion: Familial colorectal cancer may be associated with multiple occurrences of colorectal or accompanying cancers inherited by dominant or recessive transmission. MMR gene mutations, however, are less associated with mutator phenotype in familial colorectal cancer." @default.
• W2106062955 created "2016-06-24" @default.
• W2106062955 creator A5015566504 @default.
• W2106062955 creator A5020184370 @default.
• W2106062955 creator A5030572160 @default.
• W2106062955 creator A5041656942 @default.
• W2106062955 creator A5044271626 @default.
• W2106062955 creator A5047910221 @default.
• W2106062955 creator A5055037842 @default.
• W2106062955 creator A5063137841 @default.
• W2106062955 creator A5074535143 @default.
• W2106062955 creator A5075231730 @default.
• W2106062955 creator A5081783840 @default.
• W2106062955 date "2004-09-15" @default.
• W2106062955 modified "2023-10-15" @default.
• W2106062955 title "Characterization of Mutator Phenotype in Familial Colorectal Cancer Patients Not Fulfilling Amsterdam Criteria" @default.
• W2106062955 cites W1526771362 @default.
• W2106062955 cites W1894750199 @default.
• W2106062955 cites W1895983701 @default.
• W2106062955 cites W1982223627 @default.
• W2106062955 cites W1983546592 @default.
• W2106062955 cites W1983640775 @default.
• W2106062955 cites W1986937402 @default.
• W2106062955 cites W1995819860 @default.
• W2106062955 cites W2028601156 @default.
• W2106062955 cites W2032983127 @default.
• W2106062955 cites W2033689666 @default.
• W2106062955 cites W2034066784 @default.
• W2106062955 cites W2035652552 @default.
• W2106062955 cites W2052442016 @default.
• W2106062955 cites W2055071377 @default.
• W2106062955 cites W2055659684 @default.
• W2106062955 cites W2056896539 @default.
• W2106062955 cites W2061181901 @default.
• W2106062955 cites W2061343866 @default.
• W2106062955 cites W2073600121 @default.
• W2106062955 cites W2085567353 @default.
• W2106062955 cites W2088531132 @default.
• W2106062955 cites W2089791932 @default.
• W2106062955 cites W2094916175 @default.
• W2106062955 cites W2107972234 @default.
• W2106062955 cites W2112677111 @default.
• W2106062955 cites W2117618517 @default.
• W2106062955 cites W2131666734 @default.
• W2106062955 cites W2135815031 @default.
• W2106062955 cites W2142826725 @default.
• W2106062955 cites W2143501927 @default.
• W2106062955 cites W2147021638 @default.
• W2106062955 cites W2150217719 @default.
• W2106062955 cites W4237862172 @default.
• W2106062955 doi "https://doi.org/10.1158/1078-0432.ccr-04-0651" @default.
• W2106062955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15448003" @default.
• W2106062955 hasPublicationYear "2004" @default.
• W2106062955 type Work @default.
• W2106062955 sameAs 2106062955 @default.
• W2106062955 citedByCount "14" @default.
• W2106062955 countsByYear W21060629552012 @default.
• W2106062955 countsByYear W21060629552016 @default.
• W2106062955 countsByYear W21060629552017 @default.
• W2106062955 countsByYear W21060629552018 @default.
• W2106062955 countsByYear W21060629552023 @default.
• W2106062955 crossrefType "journal-article" @default.
• W2106062955 hasAuthorship W2106062955A5015566504 @default.
• W2106062955 hasAuthorship W2106062955A5020184370 @default.
• W2106062955 hasAuthorship W2106062955A5030572160 @default.
• W2106062955 hasAuthorship W2106062955A5041656942 @default.
• W2106062955 hasAuthorship W2106062955A5044271626 @default.
• W2106062955 hasAuthorship W2106062955A5047910221 @default.
• W2106062955 hasAuthorship W2106062955A5055037842 @default.
• W2106062955 hasAuthorship W2106062955A5063137841 @default.
• W2106062955 hasAuthorship W2106062955A5074535143 @default.
• W2106062955 hasAuthorship W2106062955A5075231730 @default.
• W2106062955 hasAuthorship W2106062955A5081783840 @default.
• W2106062955 hasBestOaLocation W21060629551 @default.
• W2106062955 hasConcept C104317684 @default.
• W2106062955 hasConcept C121608353 @default.
• W2106062955 hasConcept C126322002 @default.
• W2106062955 hasConcept C127716648 @default.
• W2106062955 hasConcept C143998085 @default.
• W2106062955 hasConcept C150194340 @default.
• W2106062955 hasConcept C180754005 @default.
• W2106062955 hasConcept C188997412 @default.
• W2106062955 hasConcept C190727270 @default.
• W2106062955 hasConcept C2776559941 @default.
• W2106062955 hasConcept C2778237340 @default.
• W2106062955 hasConcept C2779767149 @default.
• W2106062955 hasConcept C2780814781 @default.
• W2106062955 hasConcept C41091548 @default.
• W2106062955 hasConcept C501734568 @default.
• W2106062955 hasConcept C502942594 @default.
• W2106062955 hasConcept C526805850 @default.
• W2106062955 hasConcept C54355233 @default.
• W2106062955 hasConcept C60748783 @default.
• W2106062955 hasConcept C61320498 @default.
• W2106062955 hasConcept C71924100 @default.
• W2106062955 hasConcept C86803240 @default.
• W2106062955 hasConceptScore W2106062955C104317684 @default.
• W2106062955 hasConceptScore W2106062955C121608353 @default.

• next