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• W2106073107 endingPage "2474" @default.
• W2106073107 startingPage "2465" @default.
• W2106073107 abstract "We examined the function of the intracellular domains of the two known Drosophila Notch ligands, Delta and Serrate, by expressing wild-type and mutant forms in the developing Drosophila eye under the sevenless promoter. The expression of intracellularly truncated forms of either Delta (sev-DlTM) or Serrate (sev-SerTM) leads to extra photoreceptor phenotypes, similar to the eye phenotypes associated with loss-of-function mutations of either Notch or Delta. Consistent with the notion that the truncated ligands reduce. Notch signalling activity, the eye phenotypes of sev-DlTM and sev-SerTM are enhanced by loss-of-function mutations in the Notch pathway elements, Notch, Delta, mastermind, deltex and groucho, but are suppressed by a duplication of Delta or mutations in Hairless, a negative regulator of the pathway. These observations were extended to the molecular level by demonstrating that the expression of Enhancer of split m delta, a target of Notch signalling, is down-regulated by the truncated ligands highly expressed in neighbouring cells. We conclude that the truncated ligands act as antagonists of Notch signalling." @default.
• W2106073107 created "2016-06-24" @default.
• W2106073107 creator A5004223352 @default.
• W2106073107 creator A5067968824 @default.
• W2106073107 date "1996-08-01" @default.
• W2106073107 modified "2023-10-14" @default.
• W2106073107 title "The intracellular deletions of DELTA and SERRATE define dominant negative forms of the <i>Drosophila</i> Notch ligands" @default.
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• W2106073107 doi "https://doi.org/10.1242/dev.122.8.2465" @default.
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