FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106075344> ?p ?o ?g. }

• W2106075344 endingPage "338" @default.
• W2106075344 startingPage "335" @default.
• W2106075344 abstract "ObjectiveNeuroplasticity can be defined as the ability of the brain to adapt to environmental impacts. These adaptations include synapse formation and elimination, cortical reorganization, and neurogenesis. In epilepsy these mechanisms may become detrimental and contribute to disease progression. It has been proposed that Matrix Metalloproteinase 9 (MMP-9), a proteinase that cleaves extracellular matrix molecules, may be critically involved in aberrant synaptic formation in hippocampi of patients with Temporal Lobe Epilepsy (TLE). Here we present a case–control study designed to identify possible variants of the MMP-9 gene associated with human TLE.Material and methods218 Norwegian patients with TLE and 181 ethnically matched controls were compared in our association analysis. We also studied associations within two subgroups of TLE – Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS), and Temporal Lobe Epilepsy with childhood Febrile Seizures (TLE-FS). Single nucleotide polymorphisms (SNPs) were selected from HapMap and dbSNP databases for the MMP-9 gene on chromosome 20. We used standard haplotype analysis and multivariate explorative analysis.ResultsThere were no statistically significant associations between the analyzed SNPs in the MMP-9 gene and TLE, nor were any significant associations found with the two examined subgroups MTLE-HS and TLE-FS, confirmed by both analyses.ConclusionWe could not identify any polymorphisms of the human MMP-9 gene that were associated with TLE, MTLE-HS or TLE-FS, in the selected SNPs. However, factors that influence MMP-9 gene expression, post-transcriptional modifications, or the balance between activation and inhibition of MMP-9 may play a role in the pathogenesis of TLE and other epileptic syndromes." @default.
• W2106075344 created "2016-06-24" @default.
• W2106075344 creator A5007254070 @default.
• W2106075344 creator A5010975119 @default.
• W2106075344 creator A5011737941 @default.
• W2106075344 creator A5035015458 @default.
• W2106075344 creator A5036518866 @default.
• W2106075344 creator A5051321266 @default.
• W2106075344 creator A5066413716 @default.
• W2106075344 creator A5085842865 @default.
• W2106075344 creator A5087096006 @default.
• W2106075344 creator A5088446288 @default.
• W2106075344 date "2010-07-01" @default.
• W2106075344 modified "2023-10-03" @default.
• W2106075344 title "Temporal Lobe Epilepsy and Matrix Metalloproteinase 9: A tempting relation but negative genetic association" @default.
• W2106075344 cites W1582955006 @default.
• W2106075344 cites W1965627514 @default.
• W2106075344 cites W1968298146 @default.
• W2106075344 cites W1972928390 @default.
• W2106075344 cites W1973661730 @default.
• W2106075344 cites W1976831807 @default.
• W2106075344 cites W1976965104 @default.
• W2106075344 cites W1978916811 @default.
• W2106075344 cites W1979572620 @default.
• W2106075344 cites W1985131865 @default.
• W2106075344 cites W1994348124 @default.
• W2106075344 cites W1999371178 @default.
• W2106075344 cites W2000341627 @default.
• W2106075344 cites W2010462844 @default.
• W2106075344 cites W2041093905 @default.
• W2106075344 cites W2045700065 @default.
• W2106075344 cites W2046562305 @default.
• W2106075344 cites W2059297225 @default.
• W2106075344 cites W2069399682 @default.
• W2106075344 cites W2071937828 @default.
• W2106075344 cites W2075599910 @default.
• W2106075344 cites W2094160586 @default.
• W2106075344 cites W2096695182 @default.
• W2106075344 cites W2102444756 @default.
• W2106075344 cites W2105086774 @default.
• W2106075344 cites W2114153933 @default.
• W2106075344 cites W2115462216 @default.
• W2106075344 cites W2117308838 @default.
• W2106075344 cites W2124201800 @default.
• W2106075344 cites W2125216600 @default.
• W2106075344 cites W2129770670 @default.
• W2106075344 cites W2131601832 @default.
• W2106075344 cites W2142496250 @default.
• W2106075344 cites W2152664025 @default.
• W2106075344 cites W2162530578 @default.
• W2106075344 cites W2611531698 @default.
• W2106075344 doi "https://doi.org/10.1016/j.seizure.2010.05.003" @default.
• W2106075344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20605480" @default.
• W2106075344 hasPublicationYear "2010" @default.
• W2106075344 type Work @default.
• W2106075344 sameAs 2106075344 @default.
• W2106075344 citedByCount "12" @default.
• W2106075344 countsByYear W21060753442012 @default.
• W2106075344 countsByYear W21060753442013 @default.
• W2106075344 countsByYear W21060753442014 @default.
• W2106075344 countsByYear W21060753442015 @default.
• W2106075344 countsByYear W21060753442016 @default.
• W2106075344 countsByYear W21060753442017 @default.
• W2106075344 crossrefType "journal-article" @default.
• W2106075344 hasAuthorship W2106075344A5007254070 @default.
• W2106075344 hasAuthorship W2106075344A5010975119 @default.
• W2106075344 hasAuthorship W2106075344A5011737941 @default.
• W2106075344 hasAuthorship W2106075344A5035015458 @default.
• W2106075344 hasAuthorship W2106075344A5036518866 @default.
• W2106075344 hasAuthorship W2106075344A5051321266 @default.
• W2106075344 hasAuthorship W2106075344A5066413716 @default.
• W2106075344 hasAuthorship W2106075344A5085842865 @default.
• W2106075344 hasAuthorship W2106075344A5087096006 @default.
• W2106075344 hasAuthorship W2106075344A5088446288 @default.
• W2106075344 hasBestOaLocation W21060753441 @default.
• W2106075344 hasConcept C104317684 @default.
• W2106075344 hasConcept C135763542 @default.
• W2106075344 hasConcept C153209595 @default.
• W2106075344 hasConcept C15744967 @default.
• W2106075344 hasConcept C169760540 @default.
• W2106075344 hasConcept C197754878 @default.
• W2106075344 hasConcept C2777597344 @default.
• W2106075344 hasConcept C2778186239 @default.
• W2106075344 hasConcept C2781099131 @default.
• W2106075344 hasConcept C2781161787 @default.
• W2106075344 hasConcept C54355233 @default.
• W2106075344 hasConcept C86803240 @default.
• W2106075344 hasConceptScore W2106075344C104317684 @default.
• W2106075344 hasConceptScore W2106075344C135763542 @default.
• W2106075344 hasConceptScore W2106075344C153209595 @default.
• W2106075344 hasConceptScore W2106075344C15744967 @default.
• W2106075344 hasConceptScore W2106075344C169760540 @default.
• W2106075344 hasConceptScore W2106075344C197754878 @default.
• W2106075344 hasConceptScore W2106075344C2777597344 @default.
• W2106075344 hasConceptScore W2106075344C2778186239 @default.
• W2106075344 hasConceptScore W2106075344C2781099131 @default.
• W2106075344 hasConceptScore W2106075344C2781161787 @default.
• W2106075344 hasConceptScore W2106075344C54355233 @default.

• next