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• W2106075602 abstract "The functional significance of most alternative splicing (AS) events, especially frame-shifting ones, has been controversial. Using human–mouse comparison, we demonstrate that frame-preserving AS events adapt and get fixed more rapidly than frame-shifting AS events; selection for smaller exon size is stronger in frame-preserving exons than in frame-shifting ones. These results suggest AS events introducing mild changes are generally favored during evolution and explain the excess of shorter, frame-preserving cassette exons in present mammalian genomes. The functional significance of most alternative splicing (AS) events, especially frame-shifting ones, has been controversial. Using human–mouse comparison, we demonstrate that frame-preserving AS events adapt and get fixed more rapidly than frame-shifting AS events; selection for smaller exon size is stronger in frame-preserving exons than in frame-shifting ones. These results suggest AS events introducing mild changes are generally favored during evolution and explain the excess of shorter, frame-preserving cassette exons in present mammalian genomes." @default.
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• W2106075602 date "2007-10-01" @default.
• W2106075602 modified "2023-09-27" @default.
• W2106075602 title "Evolutionary impact of limited splicing fidelity in mammalian genes" @default.
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• W2106075602 doi "https://doi.org/10.1016/j.tig.2007.08.001" @default.
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