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• W2106076589 startingPage "2037" @default.
• W2106076589 abstract "The HIV-1 protease is a validated drug target for the design of antiretroviral drugs to combat AIDS. We previously established the sulfoximine functionality as a valid transition state mimetic (TSM) in the HIV-1 protease inhibitors (PI) design and have identified a lead pseudosymmetric compound with nanomolar enzymatic inhibitory activity. Here, we report the asymmetric synthesis of this compound and its application in the synthesis of sulfoximine-based peptidomimetic HIV-1 protease inhibitors. Molecular modeling revealed the potential mode of binding of the sulfoximine inhibitor as a TSM. The predicted absolute binding free energies suggested similar inhibitory effect as observed in our enzymatic inhibitory studies." @default.
• W2106076589 created "2016-06-24" @default.
• W2106076589 creator A5019449054 @default.
• W2106076589 creator A5036830700 @default.
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• W2106076589 date "2010-03-01" @default.
• W2106076589 modified "2023-09-25" @default.
• W2106076589 title "Design, asymmetric synthesis, and evaluation of pseudosymmetric sulfoximine inhibitors against HIV-1 protease" @default.
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• W2106076589 doi "https://doi.org/10.1016/j.bmc.2010.01.020" @default.
• W2106076589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20138769" @default.
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