Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106086136> ?p ?o ?g. }
- W2106086136 endingPage "456" @default.
- W2106086136 startingPage "445" @default.
- W2106086136 abstract "SUMMARY Coenzyme M (2-mercaptoethanesulfonate; CoM) is one of several atypical cofactors discovered in methanogenic archaea which participate in the biological reduction of CO 2 to methane. Elegantly simple, CoM, so named for its role as a methyl carrier in all methanogenic archaea, is the smallest known organic cofactor. It was thought that this cofactor was used exclusively in methanogenesis until it was recently discovered that CoM is a key cofactor in the pathway of propylene metabolism in the gram-negative soil microorganism Xanthobacter autotrophicus Py2. A four-step pathway requiring CoM converts propylene and CO 2 to acetoacetate, which feeds into central metabolism. In this process, CoM is used to activate and convert highly electrophilic epoxypropane, formed from propylene epoxidation, into a nucleophilic species that undergoes carboxylation. The unique properties of CoM provide a chemical handle for orienting compounds for site-specific redox chemistry and stereospecific catalysis. The three-dimensional structures of several of the enzymes in the pathway of propylene metabolism in defined states have been determined, providing significant insights into both the enzyme mechanisms and the role of CoM in this pathway. These studies provide the structural basis for understanding the efficacy of CoM as a handle to direct organic substrate transformations at the active sites of enzymes." @default.
- W2106086136 created "2016-06-24" @default.
- W2106086136 creator A5029712426 @default.
- W2106086136 creator A5032614009 @default.
- W2106086136 creator A5052110353 @default.
- W2106086136 creator A5064359021 @default.
- W2106086136 creator A5076659724 @default.
- W2106086136 creator A5089404032 @default.
- W2106086136 date "2008-09-01" @default.
- W2106086136 modified "2023-10-13" @default.
- W2106086136 title "Getting a Handle on the Role of Coenzyme M in Alkene Metabolism" @default.
- W2106086136 cites W1486187785 @default.
- W2106086136 cites W1500008671 @default.
- W2106086136 cites W1512398968 @default.
- W2106086136 cites W1523338792 @default.
- W2106086136 cites W1527829669 @default.
- W2106086136 cites W1529039987 @default.
- W2106086136 cites W1534406401 @default.
- W2106086136 cites W1556210765 @default.
- W2106086136 cites W1559434942 @default.
- W2106086136 cites W1560139137 @default.
- W2106086136 cites W1584539705 @default.
- W2106086136 cites W1590004020 @default.
- W2106086136 cites W1848490583 @default.
- W2106086136 cites W1849836964 @default.
- W2106086136 cites W1928158300 @default.
- W2106086136 cites W1930255804 @default.
- W2106086136 cites W1935201543 @default.
- W2106086136 cites W1966195232 @default.
- W2106086136 cites W1968344845 @default.
- W2106086136 cites W1973541487 @default.
- W2106086136 cites W1997614957 @default.
- W2106086136 cites W2006362924 @default.
- W2106086136 cites W2012709826 @default.
- W2106086136 cites W2013083986 @default.
- W2106086136 cites W2013157289 @default.
- W2106086136 cites W2014567246 @default.
- W2106086136 cites W2015642465 @default.
- W2106086136 cites W2016034432 @default.
- W2106086136 cites W2022916467 @default.
- W2106086136 cites W2024682494 @default.
- W2106086136 cites W2026603913 @default.
- W2106086136 cites W2029815939 @default.
- W2106086136 cites W2030966943 @default.
- W2106086136 cites W2031882074 @default.
- W2106086136 cites W2034234528 @default.
- W2106086136 cites W2034952698 @default.
- W2106086136 cites W2041230751 @default.
- W2106086136 cites W2051567805 @default.
- W2106086136 cites W2053771774 @default.
- W2106086136 cites W2055151902 @default.
- W2106086136 cites W2062438612 @default.
- W2106086136 cites W2065782985 @default.
- W2106086136 cites W2076545562 @default.
- W2106086136 cites W2077598919 @default.
- W2106086136 cites W2080950541 @default.
- W2106086136 cites W2081192485 @default.
- W2106086136 cites W2087670460 @default.
- W2106086136 cites W2106882534 @default.
- W2106086136 cites W2110958066 @default.
- W2106086136 cites W2125121305 @default.
- W2106086136 cites W2134074950 @default.
- W2106086136 cites W2134182758 @default.
- W2106086136 cites W2135898016 @default.
- W2106086136 cites W2141372922 @default.
- W2106086136 cites W2145141310 @default.
- W2106086136 cites W2146792151 @default.
- W2106086136 cites W2147641271 @default.
- W2106086136 cites W2149355862 @default.
- W2106086136 cites W2149391857 @default.
- W2106086136 cites W2163089766 @default.
- W2106086136 cites W2163969967 @default.
- W2106086136 cites W2168811677 @default.
- W2106086136 cites W2170575847 @default.
- W2106086136 cites W2170874906 @default.
- W2106086136 cites W4298313863 @default.
- W2106086136 doi "https://doi.org/10.1128/mmbr.00005-08" @default.
- W2106086136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2546864" @default.
- W2106086136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18772284" @default.
- W2106086136 hasPublicationYear "2008" @default.
- W2106086136 type Work @default.
- W2106086136 sameAs 2106086136 @default.
- W2106086136 citedByCount "44" @default.
- W2106086136 countsByYear W21060861362012 @default.
- W2106086136 countsByYear W21060861362013 @default.
- W2106086136 countsByYear W21060861362014 @default.
- W2106086136 countsByYear W21060861362015 @default.
- W2106086136 countsByYear W21060861362016 @default.
- W2106086136 countsByYear W21060861362017 @default.
- W2106086136 countsByYear W21060861362018 @default.
- W2106086136 countsByYear W21060861362019 @default.
- W2106086136 countsByYear W21060861362020 @default.
- W2106086136 countsByYear W21060861362021 @default.
- W2106086136 countsByYear W21060861362022 @default.
- W2106086136 countsByYear W21060861362023 @default.
- W2106086136 crossrefType "journal-article" @default.
- W2106086136 hasAuthorship W2106086136A5029712426 @default.
- W2106086136 hasAuthorship W2106086136A5032614009 @default.