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- W2106089128 abstract "The antimuscarinic activity of clozapine, an atypical antipsychotic was studied on rat anococcygeus muscle. Acetylcholine (1-128 μg mL−1) induced a concentration-dependent contraction of the smooth muscle. Clozapine (10−8-10−6 M) shifted the concentration-response curve of acetylcholine to the right in a parallel fashion without suppressing the maximum. The pA2 value was found to be 7.37 ± 0.24 and slope 0.86 ± 0.08.The data show that clozapine blocks the muscarinic receptors in a competitive manner." @default.
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- W2106089128 title "The Antimuscarinic Activity of Clozapine in Rats" @default.
- W2106089128 doi "https://doi.org/10.1111/j.2042-7158.1996.tb00648.x" @default.
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