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• W2106103439 startingPage "253" @default.
• W2106103439 abstract "Preeclampsia is a serious and common hypertensive complication of pregnancy, affecting ~5 to 8 % of pregnancies. The underlying cause of preeclampsia is believed to be placental ischemia, which causes secretion of pathogenic factors into the maternal circulation. While a number of these factors have been identified, it is likely that others remain to be elucidated. Here, we have utilized a relevant preclinical rodent model of placental ischemia-induced hypertension, the reduced uterine perfusion pressure (RUPP) model, to determine the effect of chronic placental ischemia on the underlying chorionic tissue and placental villi. Tissue from control and RUPP rats were isolated on gestational day 19 and mRNA from these tissues was subjected to microarray analysis to determine differential gene expression. At a statistical cutoff of p < 0.05, some 2,557 genes were differentially regulated between the two groups. Interestingly, only a small subset (22) of these genes exhibited changes of greater than 50 % versus control, a large proportion of which were subsequently confirmed using qRT-PCR analysis. Network analysis indicated a strong effect on inflammatory pathways, including those involving NF-κB and inflammatory cytokines. Of the most differentially expressed genes, the predominant gene classes were extracellular remodeling proteins, pro-inflammatory proteins, and a coordinated upregulation of the prolactin genes. The functional implications of these novel factors are discussed." @default.
• W2106103439 created "2016-06-24" @default.
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• W2106103439 date "2014-03-26" @default.
• W2106103439 modified "2023-09-30" @default.
• W2106103439 title "Placental ischemia induces changes in gene expression in chorionic tissue" @default.
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• W2106103439 doi "https://doi.org/10.1007/s00335-014-9505-3" @default.
• W2106103439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4238427" @default.
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• W2106103439 hasPublicationYear "2014" @default.
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