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- W2106116921 startingPage "e0139072" @default.
- W2106116921 abstract "Structural mechanisms of modulation of γ-aminobutyric acid (GABA) type A receptors by neurosteroids and hormones remain unclear. The thyroid hormone L-3,5,3'-triiodothyronine (T3) inhibits GABAA receptors at micromolar concentrations and has common features with neurosteroids such as allopregnanolone (ALLOP). Here we use functional experiments on α2β1γ2 GABAA receptors expressed in Xenopus oocytes to detect competitive interactions between T3 and an agonist (ivermectin, IVM) with a crystallographically determined binding site at subunit interfaces in the transmembrane domain of a homologous receptor (glutamate-gated chloride channel, GluCl). T3 and ALLOP also show competitive effects, supporting the presence of both a T3 and ALLOP binding site at one or more subunit interfaces. Molecular dynamics (MD) simulations over 200 ns are used to investigate the dynamics and energetics of T3 in the identified intersubunit sites. In these simulations, T3 molecules occupying all intersubunit sites (with the exception of the α-β interface) display numerous energetically favorable conformations with multiple hydrogen bonding partners, including previously implicated polar/acidic sidechains and a structurally conserved deformation in the M1 backbone." @default.
- W2106116921 created "2016-06-24" @default.
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- W2106116921 date "2015-09-30" @default.
- W2106116921 modified "2023-09-30" @default.
- W2106116921 title "Interactions of L-3,5,3'-Triiodothyronine, Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes" @default.
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- W2106116921 cites W1968048064 @default.
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- W2106116921 cites W1975239375 @default.
- W2106116921 cites W1976278777 @default.
- W2106116921 cites W1978102086 @default.
- W2106116921 cites W1982371070 @default.
- W2106116921 cites W1988921565 @default.
- W2106116921 cites W1992160317 @default.
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- W2106116921 cites W2012724805 @default.
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- W2106116921 cites W2019595267 @default.
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- W2106116921 doi "https://doi.org/10.1371/journal.pone.0139072" @default.
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