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- W2106118185 abstract "Due to the benign appearance histologically and the tumor’s conflicting malignant behavior, the term multilobular osteosarcoma has clinical and diagnostic significance and should be used exclusively for this canine neopla~ia.~ Metastasis of multilobular osteosarcoma has been reported in one other dog, in which the tumor arose in the occipital bone and metastasized to the lungs.3 We report a primary mandibular site with thoracic metastasis. The mandible is an uncommon site of origin, although invasion of the orbital space by these tumors from other sites has been reported.2 Presumptive diagnosis may be made radiographically, the characteristic feature being a faint stippled appearance within a solitary nodular maw4 Definitive diagnosis is by histologic evaluation; the unique multilobular arrangement of osseous, cartilaginous, or osteocartilaginous tissues surrounded by mesenchymal stroma of variable densities is characteristic of this Histologic features of the reported case demonstrate a previously unreported structural arrangement, in that lobular aggregates were separated by thick collagenous septa into large nodules which often differed in cellular composition from neighboring nodules. Malignant transformation may not be evident histologically, as this case illustrates. While the pulmonary masses demonstrated malignant features histologically, the recurring cranial mass retained its benign morphologic characteristics. The histogenetic origin of multilobular osteosarcoma is unknown, but these tumors may arise from periosteal elements of the membranous bones of the skull. However, reported sites of tumor origin are in bones of the chondro-" @default.
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- W2106118185 date "1989-01-01" @default.
- W2106118185 modified "2023-10-17" @default.
- W2106118185 title "Renal Dysplasia with Multiple Urogenital and Large Intestinal Anomalies in a Calf" @default.
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- W2106118185 doi "https://doi.org/10.1177/030098588902600119" @default.
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