Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106121337> ?p ?o ?g. }
- W2106121337 endingPage "403" @default.
- W2106121337 startingPage "396" @default.
- W2106121337 abstract "Abstract Obesity and related metabolic abnormalities, including insulin resistance and a state of chronic inflammation, increase the risk of hepatocellular carcinoma. Abnormal activation of the insulin-like growth factor (IGF)/ IGF-1 receptor (IGF-1R) axis is also involved in obesity-related liver tumorigenesis. In the present study, we examined the effects of (−)-epigallocatechin gallate (EGCG), a major biologically active component of green tea, on the development of diethylnitrosamine (DEN)-induced liver tumorigenesis in C57BL/KsJ-db/db (db/db) obese mice. Male db/db mice were given tap water containing 40 ppm DEN for 2 weeks and then they received drinking water containing 0.1% EGCG for 34 weeks. At sacrifice, drinking water with EGCG significantly inhibited the development of liver cell adenomas in comparison with the control EGCG-untreated group. EGCG inhibited the phosphorylation of the IGF-1R, ERK (extracellular signal-regulated kinase), Akt, GSK-3β (glycogen synthase kinase-3β), Stat3, and JNK (c-Jun NH2-terminal kinase) proteins in the livers of experimental mice. The serum levels of insulin, IGF-1, IGF-2, free fatty acid, and TNF-α were all decreased by drinking EGCG, which also decreased the expression of TNF-α, interleukin (IL)-6, IL-1β, and IL-18 mRNAs in the livers. In addition, EGCG improved liver steatosis and activated the AMP-activated kinase protein in the liver. These findings suggest that EGCG prevents obesity-related liver tumorigenesis by inhibiting the IGF/IGF-1R axis, improving hyperinsulinemia, and attenuating chronic inflammation. EGCG, therefore, may be useful in the chemoprevention of liver tumorigenesis in obese individuals. Cancer Prev Res; 4(3); 396–403. ©2011 AACR." @default.
- W2106121337 created "2016-06-24" @default.
- W2106121337 creator A5005286789 @default.
- W2106121337 creator A5030174613 @default.
- W2106121337 creator A5041284607 @default.
- W2106121337 creator A5059482754 @default.
- W2106121337 creator A5063439535 @default.
- W2106121337 creator A5065822023 @default.
- W2106121337 creator A5076725243 @default.
- W2106121337 creator A5081117532 @default.
- W2106121337 creator A5084247658 @default.
- W2106121337 creator A5085073972 @default.
- W2106121337 creator A5087582211 @default.
- W2106121337 date "2011-03-01" @default.
- W2106121337 modified "2023-09-24" @default.
- W2106121337 title "Preventive Effects of (−)-Epigallocatechin Gallate on Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BL/KsJ-db/db Mice" @default.
- W2106121337 cites W1967861333 @default.
- W2106121337 cites W1975755717 @default.
- W2106121337 cites W1976613835 @default.
- W2106121337 cites W1978281808 @default.
- W2106121337 cites W1980429742 @default.
- W2106121337 cites W1988051941 @default.
- W2106121337 cites W1988870963 @default.
- W2106121337 cites W1995501999 @default.
- W2106121337 cites W2003578093 @default.
- W2106121337 cites W2011599861 @default.
- W2106121337 cites W2021625611 @default.
- W2106121337 cites W2025262034 @default.
- W2106121337 cites W2029149880 @default.
- W2106121337 cites W2034625230 @default.
- W2106121337 cites W2038018821 @default.
- W2106121337 cites W2038314648 @default.
- W2106121337 cites W2039845199 @default.
- W2106121337 cites W2044874695 @default.
- W2106121337 cites W2052384271 @default.
- W2106121337 cites W2052656103 @default.
- W2106121337 cites W2055459745 @default.
- W2106121337 cites W2067266295 @default.
- W2106121337 cites W2068856412 @default.
- W2106121337 cites W2071288722 @default.
- W2106121337 cites W2075264528 @default.
- W2106121337 cites W2080998956 @default.
- W2106121337 cites W2099212825 @default.
- W2106121337 cites W2101063380 @default.
- W2106121337 cites W2101685363 @default.
- W2106121337 cites W2103498170 @default.
- W2106121337 cites W2114825009 @default.
- W2106121337 cites W2124056180 @default.
- W2106121337 cites W2135642745 @default.
- W2106121337 cites W2136210930 @default.
- W2106121337 cites W2137052325 @default.
- W2106121337 cites W2140871020 @default.
- W2106121337 cites W2142302251 @default.
- W2106121337 cites W2153535359 @default.
- W2106121337 cites W2157727415 @default.
- W2106121337 cites W2161654500 @default.
- W2106121337 cites W2164778116 @default.
- W2106121337 cites W2168526937 @default.
- W2106121337 cites W2614443566 @default.
- W2106121337 cites W3093642895 @default.
- W2106121337 doi "https://doi.org/10.1158/1940-6207.capr-10-0331" @default.
- W2106121337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21372039" @default.
- W2106121337 hasPublicationYear "2011" @default.
- W2106121337 type Work @default.
- W2106121337 sameAs 2106121337 @default.
- W2106121337 citedByCount "72" @default.
- W2106121337 countsByYear W21061213372012 @default.
- W2106121337 countsByYear W21061213372013 @default.
- W2106121337 countsByYear W21061213372014 @default.
- W2106121337 countsByYear W21061213372015 @default.
- W2106121337 countsByYear W21061213372016 @default.
- W2106121337 countsByYear W21061213372017 @default.
- W2106121337 countsByYear W21061213372018 @default.
- W2106121337 countsByYear W21061213372019 @default.
- W2106121337 countsByYear W21061213372020 @default.
- W2106121337 countsByYear W21061213372021 @default.
- W2106121337 countsByYear W21061213372022 @default.
- W2106121337 countsByYear W21061213372023 @default.
- W2106121337 crossrefType "journal-article" @default.
- W2106121337 hasAuthorship W2106121337A5005286789 @default.
- W2106121337 hasAuthorship W2106121337A5030174613 @default.
- W2106121337 hasAuthorship W2106121337A5041284607 @default.
- W2106121337 hasAuthorship W2106121337A5059482754 @default.
- W2106121337 hasAuthorship W2106121337A5063439535 @default.
- W2106121337 hasAuthorship W2106121337A5065822023 @default.
- W2106121337 hasAuthorship W2106121337A5076725243 @default.
- W2106121337 hasAuthorship W2106121337A5081117532 @default.
- W2106121337 hasAuthorship W2106121337A5084247658 @default.
- W2106121337 hasAuthorship W2106121337A5085073972 @default.
- W2106121337 hasAuthorship W2106121337A5087582211 @default.
- W2106121337 hasConcept C121608353 @default.
- W2106121337 hasConcept C126322002 @default.
- W2106121337 hasConcept C134018914 @default.
- W2106121337 hasConcept C164027704 @default.
- W2106121337 hasConcept C185592680 @default.
- W2106121337 hasConcept C190283241 @default.
- W2106121337 hasConcept C2776175330 @default.
- W2106121337 hasConcept C2776914184 @default.