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• W2106122696 abstract ": 01CD002 Studying pulmonary function in HIV positive tanzanian youth A. August; Geisel School of Medicine at Dartmouth, Hanover, NH/US Program/Project Purpose: Survival into childhood with an untreated HIV infection was once considered unusual, but has increased in recent years. This has spurred further interest in studying the health of adolescents living with HIV. There have been two major reports from Zimbabwe (Ferrand et al., 2007) and Malawi (Zverez et al., 2001) of a decrease in pulmonary function in HIV positive youth, especially if they had delayed onset of treatment. The purpose of this study is to investigate the pulmonary function of HIV positive Tanzanian children. This study will help determine the importance of monitoring lung function in HIV patients and if a pulmonary treatment regimen should be instituted. Structure/Method/Design: A cohort of 250 Tanzanian children between the ages of 8 and 18 with a diagnosis of HIV currently being treated at the DarDar Pediatric Program in Dar es Salaam, Tanzania will take part in the study. Pulmonary function (PFT) was assessed using spirometry to measure forced expiratory volume at one second (FEV1), forced vital capacity (FVC), FVC/FEV1 ratio, and forced expiratory flow 25% to 75% (FEF25-75) as well as pulse oximetry. Each participant was evaluated at rest. If recorded values for FVC and FEV 1 were > 70% of predicted, they were re-evaluated after moderate exercise and after administration of a bronchodilator. Normative data from healthy Malawian youth were used. The PFT data were analyzed in correlation with age of diagnosis and age at initiation of antiretroviral therapy. Outcomes & Evaluation: A preliminary analysis of the first 50 subjects has not shown any significant degree of pulmonary dysfunction nor any correlation with a delayed ART regimen. Of the 50 subjects, three were excluded for inconsistent PFT efforts. The remaining 47 subjects consisted of 17 females/30 males. Only 3 subjects had FEV 1 Going Forward: Ongoing challenges include obtaining consistent data from younger subjects as well as timely patient acquisition. We anticipate meeting our goal of 250 subjects by late spring 2015. Funding: This project is supported by internal funds available through the Medical Schools at Muhimbili University and Dartmouth. Funding for the author’s participation was provided by the DIHG-DICKEY International Health Fellowship and Helen’s Fund for pediatric research at the Children’s Hospital at Dartmouth." @default.
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• W2106122696 date "2015-03-12" @default.
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• W2106122696 title "High risk HPV persistence among HIV-infected young women in South Africa" @default.
• W2106122696 doi "https://doi.org/10.1016/j.aogh.2015.02.519" @default.
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