FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106123906> ?p ?o ?g. }

• W2106123906 abstract "The primary motor cortex has an important role in the precise execution of learned motor responses. During motor learning, synaptic efficacy between sensory and primary motor cortical neurons is enhanced, possibly involving long-term potentiation and N-methyl-D-aspartate (NMDA)-specific glutamate receptor function. To investigate whether NMDA receptor in the primary motor cortex can act as a coincidence detector for activity-dependent changes in synaptic strength and associative learning, here we generate mice with deletion of the Grin1 gene, encoding the essential NMDA receptor subunit 1 (GluN1), specifically in the primary motor cortex. The loss of NMDA receptor function impairs primary motor cortex long-term potentiation in vivo. Importantly, it impairs the synaptic efficacy between the primary somatosensory and primary motor cortices and significantly reduces classically conditioned eyeblink responses. Furthermore, compared with wild-type littermates, mice lacking NMDA receptors in the primary motor cortex show slower learning in Skinner-box tasks. Thus, primary motor cortex NMDA receptors are necessary for activity-dependent synaptic strengthening and associative learning. Motor cortex NMDA receptors have a key role in the acquisition of associative memories. Hasan et al. generate mice lacking NMDA receptor activity in the motor cortex and find that this impairs LTP, strengthening of synapses between somatosensory and motor cortices, and associative learning." @default.
• W2106123906 created "2016-06-24" @default.
• W2106123906 creator A5022126002 @default.
• W2106123906 creator A5030941320 @default.
• W2106123906 creator A5031429133 @default.
• W2106123906 creator A5062187111 @default.
• W2106123906 creator A5078629574 @default.
• W2106123906 creator A5080600710 @default.
• W2106123906 creator A5088334122 @default.
• W2106123906 date "2013-08-27" @default.
• W2106123906 modified "2023-10-18" @default.
• W2106123906 title "Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice" @default.
• W2106123906 cites W1481762643 @default.
• W2106123906 cites W1561430338 @default.
• W2106123906 cites W1954127107 @default.
• W2106123906 cites W1966155655 @default.
• W2106123906 cites W1969643417 @default.
• W2106123906 cites W1970607307 @default.
• W2106123906 cites W1973216683 @default.
• W2106123906 cites W1974236821 @default.
• W2106123906 cites W1976722519 @default.
• W2106123906 cites W1980877787 @default.
• W2106123906 cites W1983903556 @default.
• W2106123906 cites W1990354312 @default.
• W2106123906 cites W1994338842 @default.
• W2106123906 cites W1995367941 @default.
• W2106123906 cites W1996874802 @default.
• W2106123906 cites W2000308859 @default.
• W2106123906 cites W2005392553 @default.
• W2106123906 cites W2010778459 @default.
• W2106123906 cites W2023334117 @default.
• W2106123906 cites W2029261862 @default.
• W2106123906 cites W2033602138 @default.
• W2106123906 cites W2039905869 @default.
• W2106123906 cites W2039956044 @default.
• W2106123906 cites W2047405616 @default.
• W2106123906 cites W2050760503 @default.
• W2106123906 cites W2064711204 @default.
• W2106123906 cites W2067071866 @default.
• W2106123906 cites W2070297181 @default.
• W2106123906 cites W2070501686 @default.
• W2106123906 cites W2072583006 @default.
• W2106123906 cites W2075358425 @default.
• W2106123906 cites W2087816970 @default.
• W2106123906 cites W2087896811 @default.
• W2106123906 cites W2094798942 @default.
• W2106123906 cites W2094933391 @default.
• W2106123906 cites W2099721491 @default.
• W2106123906 cites W2103212315 @default.
• W2106123906 cites W2104879106 @default.
• W2106123906 cites W2111128547 @default.
• W2106123906 cites W2112927743 @default.
• W2106123906 cites W2115065097 @default.
• W2106123906 cites W2121406336 @default.
• W2106123906 cites W2122591357 @default.
• W2106123906 cites W2131141854 @default.
• W2106123906 cites W2138419760 @default.
• W2106123906 cites W2140885691 @default.
• W2106123906 cites W2142616158 @default.
• W2106123906 cites W2148691225 @default.
• W2106123906 cites W2150950385 @default.
• W2106123906 cites W2151010453 @default.
• W2106123906 cites W2155628709 @default.
• W2106123906 cites W2158935809 @default.
• W2106123906 cites W2164535356 @default.
• W2106123906 cites W2253776861 @default.
• W2106123906 cites W2431771327 @default.
• W2106123906 cites W4214891130 @default.
• W2106123906 cites W4240980427 @default.
• W2106123906 cites W4242023516 @default.
• W2106123906 doi "https://doi.org/10.1038/ncomms3258" @default.
• W2106123906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3759079" @default.
• W2106123906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23978820" @default.
• W2106123906 hasPublicationYear "2013" @default.
• W2106123906 type Work @default.
• W2106123906 sameAs 2106123906 @default.
• W2106123906 citedByCount "75" @default.
• W2106123906 countsByYear W21061239062013 @default.
• W2106123906 countsByYear W21061239062014 @default.
• W2106123906 countsByYear W21061239062015 @default.
• W2106123906 countsByYear W21061239062016 @default.
• W2106123906 countsByYear W21061239062017 @default.
• W2106123906 countsByYear W21061239062018 @default.
• W2106123906 countsByYear W21061239062019 @default.
• W2106123906 countsByYear W21061239062020 @default.
• W2106123906 countsByYear W21061239062021 @default.
• W2106123906 countsByYear W21061239062022 @default.
• W2106123906 countsByYear W21061239062023 @default.
• W2106123906 crossrefType "journal-article" @default.
• W2106123906 hasAuthorship W2106123906A5022126002 @default.
• W2106123906 hasAuthorship W2106123906A5030941320 @default.
• W2106123906 hasAuthorship W2106123906A5031429133 @default.
• W2106123906 hasAuthorship W2106123906A5062187111 @default.
• W2106123906 hasAuthorship W2106123906A5078629574 @default.
• W2106123906 hasAuthorship W2106123906A5080600710 @default.
• W2106123906 hasAuthorship W2106123906A5088334122 @default.
• W2106123906 hasBestOaLocation W21061239061 @default.
• W2106123906 hasConcept C107690735 @default.
• W2106123906 hasConcept C15744967 @default.
• W2106123906 hasConcept C160268369 @default.

• next