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- W2106128418 abstract "To assess the in vitro activity of the FDA-approved antihelminthic drug pyrvinium pamoate against Entamoeba histolytica and Giardia intestinalis. A head-to-head comparison of a standard radiolabelled thymidine incorporation assay and the SYBR Green I-based fluorescence assay for determination of in vitro inhibition by pyrvinium and metronidazole was performed. The 50% inhibitory concentration (IC50) for treatment of E. histolytica with pyrvinium was 4–5 µM for both assays compared with 1–2 µM for metronidazole. For pyrvinium treatment of G. intestinalis, an IC50 of ∼12 µM was determined by the radiolabelled thymidine assay alone, with maximum inhibition around 60%. In contrast, the IC50 for metronidazole treatment using this assay was ∼2 µM. Pyrvinium is a potential gut lumen agent for treatment of intestinal amoebiasis, but possibly not for giardiasis. SYBR Green I is an alternative screening method for E. histolytica, but not G. intestinalis." @default.
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- W2106128418 date "2009-08-18" @default.
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- W2106128418 title "In vitro activity of pyrvinium pamoate against Entamoeba histolytica and Giardia intestinalis using radiolabelled thymidine incorporation and an SYBR Green I-based fluorescence assay" @default.
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- W2106128418 doi "https://doi.org/10.1093/jac/dkp296" @default.
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