FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106129342> ?p ?o ?g. }

• W2106129342 endingPage "e3558" @default.
• W2106129342 startingPage "e3558" @default.
• W2106129342 abstract "Tuberous sclerosis complex (TSC), a tumor syndrome caused by mutations in TSC1 or TSC2 genes, is characterized by the development of hamartomas. We previously isolated, from an angiomyolipoma of a TSC2 patient, a homogenous population of smooth muscle-like cells (TSC2(-/-) ASM cells) that have a mutation in the TSC2 gene as well as TSC2 loss of heterozygosity (LOH) and consequently, do not produce the TSC2 gene product, tuberin. TSC2(-/-) ASM cell proliferation is EGF-dependent.Effects of EGF on proliferation of TSC2(-/-) ASM cells and TSC2(-/-) ASM cells transfected with TSC2 gene were determined. In contrast to TSC2(-/-) ASM cells, growth of TSC2-transfected cells was not dependent on EGF. Moreover, phosphorylation of Akt, PTEN, Erk and S6 was significantly decreased. EGF is a proliferative factor of TSC2(-/-) ASM cells. Exposure of TSC2(-/-) ASM cells to anti-EGFR antibodies significantly inhibited their proliferation, reverted reactivity to HMB45 antibody, a marker of TSC2(-/-) cell phenotype, and inhibited constitutive phosphorylation of S6 and ERK. Exposure of TSC2(-/-) ASM cells to rapamycin reduced the proliferation rate, but only when added at plating time. Although rapamycin efficiently inhibited S6 phosphorylation, it was less efficient than anti-EGFR antibody in reverting HMB45 reactivity and blocking ERK phosphorylation. In TSC2(-/-) ASM cells specific PI3K inhibitors (e.g. LY294002, wortmannin) and Akt1 siRNA had little effect on S6 and ERK phosphorylation. Following TSC2-gene transfection, Akt inhibitor sensitivity was observed.Our results show that an EGF independent pathway is more important than that involving IGF-I for growth and survival of TSC(-/-) ASM cells, and such EGF-dependency is the result of the lack of tuberin." @default.
• W2106129342 created "2016-06-24" @default.
• W2106129342 creator A5012607430 @default.
• W2106129342 creator A5015395886 @default.
• W2106129342 creator A5041843942 @default.
• W2106129342 creator A5053241457 @default.
• W2106129342 creator A5055981443 @default.
• W2106129342 creator A5059088289 @default.
• W2106129342 date "2008-10-29" @default.
• W2106129342 modified "2023-10-07" @default.
• W2106129342 title "Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2−/− Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM" @default.
• W2106129342 cites W1587932799 @default.
• W2106129342 cites W1761706969 @default.
• W2106129342 cites W1918600217 @default.
• W2106129342 cites W1969161473 @default.
• W2106129342 cites W1987826022 @default.
• W2106129342 cites W1998038367 @default.
• W2106129342 cites W2011063821 @default.
• W2106129342 cites W2011282245 @default.
• W2106129342 cites W2012083843 @default.
• W2106129342 cites W2018293173 @default.
• W2106129342 cites W2020457650 @default.
• W2106129342 cites W2041811289 @default.
• W2106129342 cites W2042530540 @default.
• W2106129342 cites W2044407816 @default.
• W2106129342 cites W2050790870 @default.
• W2106129342 cites W2051765792 @default.
• W2106129342 cites W2067710601 @default.
• W2106129342 cites W2079990039 @default.
• W2106129342 cites W2094622904 @default.
• W2106129342 cites W2099615457 @default.
• W2106129342 cites W2119979409 @default.
• W2106129342 cites W2125287213 @default.
• W2106129342 cites W2134757689 @default.
• W2106129342 cites W2137563421 @default.
• W2106129342 cites W2145804860 @default.
• W2106129342 cites W2145887356 @default.
• W2106129342 cites W2152973392 @default.
• W2106129342 cites W2157497892 @default.
• W2106129342 cites W2159623942 @default.
• W2106129342 cites W2170936754 @default.
• W2106129342 cites W2178919960 @default.
• W2106129342 cites W2184718406 @default.
• W2106129342 cites W2235106477 @default.
• W2106129342 cites W2432234794 @default.
• W2106129342 cites W4237534021 @default.
• W2106129342 doi "https://doi.org/10.1371/journal.pone.0003558" @default.
• W2106129342 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2570214" @default.
• W2106129342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18958173" @default.
• W2106129342 hasPublicationYear "2008" @default.
• W2106129342 type Work @default.
• W2106129342 sameAs 2106129342 @default.
• W2106129342 citedByCount "26" @default.
• W2106129342 countsByYear W21061293422012 @default.
• W2106129342 countsByYear W21061293422013 @default.
• W2106129342 countsByYear W21061293422014 @default.
• W2106129342 countsByYear W21061293422015 @default.
• W2106129342 countsByYear W21061293422016 @default.
• W2106129342 countsByYear W21061293422017 @default.
• W2106129342 countsByYear W21061293422018 @default.
• W2106129342 countsByYear W21061293422021 @default.
• W2106129342 countsByYear W21061293422022 @default.
• W2106129342 crossrefType "journal-article" @default.
• W2106129342 hasAuthorship W2106129342A5012607430 @default.
• W2106129342 hasAuthorship W2106129342A5015395886 @default.
• W2106129342 hasAuthorship W2106129342A5041843942 @default.
• W2106129342 hasAuthorship W2106129342A5053241457 @default.
• W2106129342 hasAuthorship W2106129342A5055981443 @default.
• W2106129342 hasAuthorship W2106129342A5059088289 @default.
• W2106129342 hasBestOaLocation W21061293421 @default.
• W2106129342 hasConcept C11960822 @default.
• W2106129342 hasConcept C142724271 @default.
• W2106129342 hasConcept C153911025 @default.
• W2106129342 hasConcept C185592680 @default.
• W2106129342 hasConcept C2776773979 @default.
• W2106129342 hasConcept C2778980267 @default.
• W2106129342 hasConcept C2779422105 @default.
• W2106129342 hasConcept C502942594 @default.
• W2106129342 hasConcept C54009773 @default.
• W2106129342 hasConcept C54355233 @default.
• W2106129342 hasConcept C55493867 @default.
• W2106129342 hasConcept C57074206 @default.
• W2106129342 hasConcept C62112901 @default.
• W2106129342 hasConcept C62478195 @default.
• W2106129342 hasConcept C71924100 @default.
• W2106129342 hasConcept C75217442 @default.
• W2106129342 hasConcept C81885089 @default.
• W2106129342 hasConcept C86554907 @default.
• W2106129342 hasConcept C86803240 @default.
• W2106129342 hasConcept C95444343 @default.
• W2106129342 hasConceptScore W2106129342C11960822 @default.
• W2106129342 hasConceptScore W2106129342C142724271 @default.
• W2106129342 hasConceptScore W2106129342C153911025 @default.
• W2106129342 hasConceptScore W2106129342C185592680 @default.
• W2106129342 hasConceptScore W2106129342C2776773979 @default.
• W2106129342 hasConceptScore W2106129342C2778980267 @default.
• W2106129342 hasConceptScore W2106129342C2779422105 @default.
• W2106129342 hasConceptScore W2106129342C502942594 @default.

• next