FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106130160> ?p ?o ?g. }

• W2106130160 endingPage "499" @default.
• W2106130160 startingPage "491" @default.
• W2106130160 abstract "Objective Somatotroph adenomas causing acromegaly are histologically classified into densely granulated (DG) and sparsely granulated (SG) subtypes with different morphology, clinical characteristics and treatment outcomes. Granulation pattern has been reported to co-segregate with a recurrent mutation at codon 49 in growth hormone receptor ( GHR ) and GSP oncogene. This study examines response to the octreotide suppression test (OST) in relation to granulation pattern and mutation in GHR and GSP . Design This is a retrospective, single-centre study of 52 patients with pathologically confirmed somatotroph adenoma who were naïve to medical therapy presenting between January 2001 and October 2010. Methods Clinical, radiological and hormonal data at diagnosis were recorded. GHR and GSP were genotyped, granulation pattern determined and response to the OST measured. Results SG adenomas were larger ( P =0.038), occurred in younger patients ( P =0.029), were more common in females ( P =0.026) and were more invasive ( P <0.0001 and P =0.001), with diminished responses to the OST ( P =0.007) compared with DG adenomas. GSP mutation was unrelated to granulation pattern but associated with smaller tumours ( P =0.027), producing more GH ( P =0.048) that responded better to the OST ( P =0.022). Codon 49 of GHR was not mutated. Conclusions Adenoma histological phenotype, not genotype, corresponds to clinical and biochemical characteristics and response to the OST. SG adenomas constitute a clinically more unfavourable subtype but are not associated with GHR mutations in our series. Ascertainment of the adenoma subtype may become an important consideration in the management of acromegaly." @default.
• W2106130160 created "2016-06-24" @default.
• W2106130160 creator A5004676975 @default.
• W2106130160 creator A5008290002 @default.
• W2106130160 creator A5023974304 @default.
• W2106130160 creator A5028857139 @default.
• W2106130160 creator A5079253584 @default.
• W2106130160 creator A5086206120 @default.
• W2106130160 date "2013-04-01" @default.
• W2106130160 modified "2023-10-14" @default.
• W2106130160 title "Granulation pattern, but not GSP or GHR mutation, is associated with clinical characteristics in somatostatin-naïve patients with somatotroph adenomas" @default.
• W2106130160 cites W1568250264 @default.
• W2106130160 cites W1581986083 @default.
• W2106130160 cites W1971523453 @default.
• W2106130160 cites W1974366727 @default.
• W2106130160 cites W1983725128 @default.
• W2106130160 cites W1989900857 @default.
• W2106130160 cites W1990401009 @default.
• W2106130160 cites W2004179893 @default.
• W2106130160 cites W2009310850 @default.
• W2106130160 cites W2014729851 @default.
• W2106130160 cites W2018931885 @default.
• W2106130160 cites W2023345834 @default.
• W2106130160 cites W2027981735 @default.
• W2106130160 cites W2032803507 @default.
• W2106130160 cites W2033641830 @default.
• W2106130160 cites W2035389128 @default.
• W2106130160 cites W2039094079 @default.
• W2106130160 cites W2039216400 @default.
• W2106130160 cites W2054935117 @default.
• W2106130160 cites W2062920754 @default.
• W2106130160 cites W2065920994 @default.
• W2106130160 cites W2068248473 @default.
• W2106130160 cites W2072714804 @default.
• W2106130160 cites W2093005407 @default.
• W2106130160 cites W2100396774 @default.
• W2106130160 cites W2102667039 @default.
• W2106130160 cites W2108609202 @default.
• W2106130160 cites W2111216596 @default.
• W2106130160 cites W2115619137 @default.
• W2106130160 cites W2118341413 @default.
• W2106130160 cites W2139508757 @default.
• W2106130160 cites W2147567199 @default.
• W2106130160 cites W2149468301 @default.
• W2106130160 cites W2152882114 @default.
• W2106130160 cites W2155280850 @default.
• W2106130160 cites W2155465680 @default.
• W2106130160 cites W2166330620 @default.
• W2106130160 cites W2172067681 @default.
• W2106130160 cites W4253248478 @default.
• W2106130160 cites W4256608891 @default.
• W2106130160 doi "https://doi.org/10.1530/eje-12-0864" @default.
• W2106130160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23288882" @default.
• W2106130160 hasPublicationYear "2013" @default.
• W2106130160 type Work @default.
• W2106130160 sameAs 2106130160 @default.
• W2106130160 citedByCount "94" @default.
• W2106130160 countsByYear W21061301602013 @default.
• W2106130160 countsByYear W21061301602014 @default.
• W2106130160 countsByYear W21061301602015 @default.
• W2106130160 countsByYear W21061301602016 @default.
• W2106130160 countsByYear W21061301602017 @default.
• W2106130160 countsByYear W21061301602018 @default.
• W2106130160 countsByYear W21061301602019 @default.
• W2106130160 countsByYear W21061301602020 @default.
• W2106130160 countsByYear W21061301602021 @default.
• W2106130160 countsByYear W21061301602022 @default.
• W2106130160 countsByYear W21061301602023 @default.
• W2106130160 crossrefType "journal-article" @default.
• W2106130160 hasAuthorship W2106130160A5004676975 @default.
• W2106130160 hasAuthorship W2106130160A5008290002 @default.
• W2106130160 hasAuthorship W2106130160A5023974304 @default.
• W2106130160 hasAuthorship W2106130160A5028857139 @default.
• W2106130160 hasAuthorship W2106130160A5079253584 @default.
• W2106130160 hasAuthorship W2106130160A5086206120 @default.
• W2106130160 hasBestOaLocation W21061301601 @default.
• W2106130160 hasConcept C113675107 @default.
• W2106130160 hasConcept C126322002 @default.
• W2106130160 hasConcept C134018914 @default.
• W2106130160 hasConcept C142724271 @default.
• W2106130160 hasConcept C2776297358 @default.
• W2106130160 hasConcept C2777428134 @default.
• W2106130160 hasConcept C2777433750 @default.
• W2106130160 hasConcept C2984496839 @default.
• W2106130160 hasConcept C71315377 @default.
• W2106130160 hasConcept C71924100 @default.
• W2106130160 hasConcept C90924648 @default.
• W2106130160 hasConceptScore W2106130160C113675107 @default.
• W2106130160 hasConceptScore W2106130160C126322002 @default.
• W2106130160 hasConceptScore W2106130160C134018914 @default.
• W2106130160 hasConceptScore W2106130160C142724271 @default.
• W2106130160 hasConceptScore W2106130160C2776297358 @default.
• W2106130160 hasConceptScore W2106130160C2777428134 @default.
• W2106130160 hasConceptScore W2106130160C2777433750 @default.
• W2106130160 hasConceptScore W2106130160C2984496839 @default.
• W2106130160 hasConceptScore W2106130160C71315377 @default.
• W2106130160 hasConceptScore W2106130160C71924100 @default.
• W2106130160 hasConceptScore W2106130160C90924648 @default.

• next