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• W2106134042 endingPage "F207" @default.
• W2106134042 startingPage "F199" @default.
• W2106134042 abstract "Gene-targeting studies in mice demonstrate that the renin-angiotensin system is required for the proper development of the renal medulla. In the absence of angiotensin II (ANG II) or the ANG II type 1 (AT 1 ) receptor, mice exhibit poor papillary development and a severe urinary-concentrating defect. These findings imply that the ureteric bud (UB) and its branches are targets for ANG II actions during renal development. However, direct evidence linking ANG II with UB-branching morphogenesis does not exist. Using immunohistochemistry, we demonstrated that UB-derived epithelia express angiotensinogen (Ao) and the AT 1 receptor during murine metanephrogenesis. Ao and AT 1 receptors are expressed in the UB branches and to a lesser extent in the stromal mesenchyme. AT 1 receptor expression in UB-derived epithelia increased from embryo day 12 to day 16 and was observed on both luminal and basolateral membranes. In accord with these findings, cultured murine UB cells express AT 1 receptor protein and mRNA. Treatment of UB cells cultured in three-dimensional type I collagen gels with ANG II (10 – 7 to 10 – 5 M) elicits a dose-related increase in the number of cells that have primary and secondary branches. These effects of ANG II on UB branching are abrogated by pretreatment with the AT 1 receptor antagonist candesartan. These data demonstrate a direct and independent role for ANG II acting via AT 1 receptors on UB cell branching in vitro. The presence of Ao in the stroma and AT 1 on UB cells supports the notion that cross talk between stroma and epithelial cells is crucial to epithelial branching morphogenesis in the developing kidney." @default.
• W2106134042 created "2016-06-24" @default.
• W2106134042 creator A5024107838 @default.
• W2106134042 creator A5037397236 @default.
• W2106134042 date "2003-08-01" @default.
• W2106134042 modified "2023-10-13" @default.
• W2106134042 title "A role for angiotensin II AT₁receptors in ureteric bud cell branching" @default.
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• W2106134042 doi "https://doi.org/10.1152/ajprenal.00401.2002" @default.
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