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- W2106136941 abstract "Polymorphisms in the interleukin-4 receptor α chain (IL-4Rα) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of IL-4Rα has been associated with severe asthma, especially in African Americans. We show that mice carrying the Q576R polymorphism exhibited intense allergen-induced airway inflammation and remodeling. The Q576R polymorphism did not affect proximal signal transducer and activator of transcription (STAT) 6 activation, but synergized with STAT6 in a gene target– and tissue-specific manner to mediate heightened expression of a subset of IL-4– and IL-13–responsive genes involved in allergic inflammation. Our findings indicate that the Q576R polymorphism directly promotes asthma in carrier populations by selectively augmenting IL-4Rα–dependent signaling." @default.
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- W2106136941 date "2009-09-21" @default.
- W2106136941 modified "2023-10-13" @default.
- W2106136941 title "Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma" @default.
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- W2106136941 doi "https://doi.org/10.1084/jem.20091480" @default.
- W2106136941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2757875" @default.
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- W2106136941 hasPublicationYear "2009" @default.
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