FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106168045> ?p ?o ?g. }

• W2106168045 abstract "Recent studies have linked chemotherapy resistance to the altered expression of microRNAs (miRNAs). Thus, miRNA-based approaches to modulating sensitivity to temozolomide (TMZ) may overcome chemoresistance. The aim of the present study was to investigate whether miR-136 could modulates glioma cell sensitivity to TMZ.The proliferation of glioma U251 cell line was evaluated by MTT assay. The expression of astrocyte elevated gene-1 (AEG-1)was detected by real‑time polymerase chain reaction (RT-PCR)and Western blot. The luciferase reporter gene was used to test whether AEG-1 was the target of the miR-136.The MTT assay showed that U251 cells with miR-136 overexpression were significantly more sensitive to the therapy of TMZ than control cells. Luciferase assays revealed that miR-136 directly targeted the 3'UTR of AEG-1. qRT-PCR and western blotting analysis found that AEG-1 expression at the mRNA and protein levels decreased in the miR-136 mimic-treatment group relative to control group. Downregulation of AEG-1 expression by siRNAs, U251 cells became more sensitive to the therapy of TMZ. In addition, the enhanced growth-inhibitory effect by the miR-136 mimics transfection was enhanced after the addition of AEG-1 siRNA.The present study provides the first evidence that miR-136 plays a key role in TMZ resistance by targeting the AEG-1 protein in glioma cell line, suggesting that miR-136 can be used to predict a patient's response to TMZ therapy as well as serve as a novel potential maker for glioma therapy.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_173." @default.
• W2106168045 created "2016-06-24" @default.
• W2106168045 creator A5047314367 @default.
• W2106168045 creator A5053640134 @default.
• W2106168045 creator A5057055806 @default.
• W2106168045 creator A5070674026 @default.
• W2106168045 creator A5081965195 @default.
• W2106168045 creator A5084257844 @default.
• W2106168045 date "2014-09-30" @default.
• W2106168045 modified "2023-10-15" @default.
• W2106168045 title "MiR-136 modulates glioma cell sensitivity to temozolomide by targeting astrocyte elevated gene-1" @default.
• W2106168045 cites W1710176300 @default.
• W2106168045 cites W1967832728 @default.
• W2106168045 cites W1978337436 @default.
• W2106168045 cites W2008364361 @default.
• W2106168045 cites W2014946489 @default.
• W2106168045 cites W2027462971 @default.
• W2106168045 cites W2030642913 @default.
• W2106168045 cites W2036044314 @default.
• W2106168045 cites W2036231601 @default.
• W2106168045 cites W2058148459 @default.
• W2106168045 cites W2073703919 @default.
• W2106168045 cites W2096287682 @default.
• W2106168045 cites W2096724244 @default.
• W2106168045 cites W2102326716 @default.
• W2106168045 cites W2103112228 @default.
• W2106168045 cites W2113281755 @default.
• W2106168045 cites W2123748842 @default.
• W2106168045 cites W2126940189 @default.
• W2106168045 cites W2131250676 @default.
• W2106168045 cites W2150296976 @default.
• W2106168045 cites W2153210794 @default.
• W2106168045 cites W2160687134 @default.
• W2106168045 cites W2161702288 @default.
• W2106168045 cites W2162780908 @default.
• W2106168045 cites W2333469504 @default.
• W2106168045 doi "https://doi.org/10.1186/s13000-014-0173-0" @default.
• W2106168045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4195982" @default.
• W2106168045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25266957" @default.
• W2106168045 hasPublicationYear "2014" @default.
• W2106168045 type Work @default.
• W2106168045 sameAs 2106168045 @default.
• W2106168045 citedByCount "41" @default.
• W2106168045 countsByYear W21061680452015 @default.
• W2106168045 countsByYear W21061680452016 @default.
• W2106168045 countsByYear W21061680452017 @default.
• W2106168045 countsByYear W21061680452018 @default.
• W2106168045 countsByYear W21061680452019 @default.
• W2106168045 countsByYear W21061680452020 @default.
• W2106168045 countsByYear W21061680452021 @default.
• W2106168045 countsByYear W21061680452022 @default.
• W2106168045 countsByYear W21061680452023 @default.
• W2106168045 crossrefType "journal-article" @default.
• W2106168045 hasAuthorship W2106168045A5047314367 @default.
• W2106168045 hasAuthorship W2106168045A5053640134 @default.
• W2106168045 hasAuthorship W2106168045A5057055806 @default.
• W2106168045 hasAuthorship W2106168045A5070674026 @default.
• W2106168045 hasAuthorship W2106168045A5081965195 @default.
• W2106168045 hasAuthorship W2106168045A5084257844 @default.
• W2106168045 hasBestOaLocation W21061680451 @default.
• W2106168045 hasConcept C104317684 @default.
• W2106168045 hasConcept C111335760 @default.
• W2106168045 hasConcept C127561419 @default.
• W2106168045 hasConcept C134018914 @default.
• W2106168045 hasConcept C145059251 @default.
• W2106168045 hasConcept C153911025 @default.
• W2106168045 hasConcept C22615655 @default.
• W2106168045 hasConcept C2776415932 @default.
• W2106168045 hasConcept C2777389519 @default.
• W2106168045 hasConcept C2777542381 @default.
• W2106168045 hasConcept C2778227246 @default.
• W2106168045 hasConcept C2780783641 @default.
• W2106168045 hasConcept C502942594 @default.
• W2106168045 hasConcept C529278444 @default.
• W2106168045 hasConcept C54009773 @default.
• W2106168045 hasConcept C54355233 @default.
• W2106168045 hasConcept C55493867 @default.
• W2106168045 hasConcept C62112901 @default.
• W2106168045 hasConcept C81885089 @default.
• W2106168045 hasConcept C86803240 @default.
• W2106168045 hasConceptScore W2106168045C104317684 @default.
• W2106168045 hasConceptScore W2106168045C111335760 @default.
• W2106168045 hasConceptScore W2106168045C127561419 @default.
• W2106168045 hasConceptScore W2106168045C134018914 @default.
• W2106168045 hasConceptScore W2106168045C145059251 @default.
• W2106168045 hasConceptScore W2106168045C153911025 @default.
• W2106168045 hasConceptScore W2106168045C22615655 @default.
• W2106168045 hasConceptScore W2106168045C2776415932 @default.
• W2106168045 hasConceptScore W2106168045C2777389519 @default.
• W2106168045 hasConceptScore W2106168045C2777542381 @default.
• W2106168045 hasConceptScore W2106168045C2778227246 @default.
• W2106168045 hasConceptScore W2106168045C2780783641 @default.
• W2106168045 hasConceptScore W2106168045C502942594 @default.
• W2106168045 hasConceptScore W2106168045C529278444 @default.
• W2106168045 hasConceptScore W2106168045C54009773 @default.
• W2106168045 hasConceptScore W2106168045C54355233 @default.
• W2106168045 hasConceptScore W2106168045C55493867 @default.
• W2106168045 hasConceptScore W2106168045C62112901 @default.
• W2106168045 hasConceptScore W2106168045C81885089 @default.
• W2106168045 hasConceptScore W2106168045C86803240 @default.

• next