FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106171330> ?p ?o ?g. }

• W2106171330 endingPage "H113" @default.
• W2106171330 startingPage "H106" @default.
• W2106171330 abstract "We tested whether a decrease in the ratio of interleukin-10 (IL-10) to tumor necrosis factor-alpha (TNF-alpha) correlates with the decrease in cardiac function in heart failure. It has been suggested that TNF-alpha plays a role in the progression of heart failure, and the effect of TNF-alpha in many tissues is modulated by IL-10. Any relation of these two cytokines to heart failure has never been examined. Cardiac function was assessed by echocardiographic and hemodynamic techniques in coronary artery-ligated rats at 1, 4, 8, and 16 wk after myocardial infarction (MI). Membrane-bound and soluble fractions of TNF-alpha and IL-10 proteins, the ratio of TNF-alpha to IL-10, and TNF-alpha and IL-10 mRNA levels were analyzed. Losartan was used to modify cardiac function in rats 4 wk after MI to further validate the relation between the IL-10-to-TNF-alpha ratio and cardiac function. Cardiac function deteriorated with time in all coronary artery-ligated groups, with severe failure at 16 wk after MI. Membrane-bound and soluble TNF-alpha protein fractions were increased 1 and 4 wk after MI, whereas TNF-alpha mRNA was increased 4 and 8 wk after MI. Membrane-bound IL-10 protein and mRNA levels were decreased 4, 8, and 16 wk after MI. The decrease in the IL-10-to-TNF-alpha protein ratio in all coronary artery-ligated groups correlated with the depressed cardiac function. Losartan improved cardiac function, membrane-bound and soluble TNF-alpha and IL-10 protein levels, the ratio of IL-10 to TNF-alpha, and IL-10 mRNA. This study suggests that a decrease in IL-10 and IL-10-to-TNF-alpha ratio correlates with depressed cardiac function." @default.
• W2106171330 created "2016-06-24" @default.
• W2106171330 creator A5005716248 @default.
• W2106171330 creator A5027847601 @default.
• W2106171330 creator A5048278410 @default.
• W2106171330 date "2006-07-01" @default.
• W2106171330 modified "2023-10-14" @default.
• W2106171330 title "Significance of changes in TNF-α and IL-10 levels in the progression of heart failure subsequent to myocardial infarction" @default.
• W2106171330 cites W1530149822 @default.
• W2106171330 cites W1555113073 @default.
• W2106171330 cites W1937813991 @default.
• W2106171330 cites W1971323774 @default.
• W2106171330 cites W1973849327 @default.
• W2106171330 cites W1974604145 @default.
• W2106171330 cites W1975408926 @default.
• W2106171330 cites W1981540584 @default.
• W2106171330 cites W1999881028 @default.
• W2106171330 cites W2002046257 @default.
• W2106171330 cites W2003701386 @default.
• W2106171330 cites W2012194278 @default.
• W2106171330 cites W2013965008 @default.
• W2106171330 cites W2014201393 @default.
• W2106171330 cites W2023687907 @default.
• W2106171330 cites W2034262643 @default.
• W2106171330 cites W2038613403 @default.
• W2106171330 cites W2040227994 @default.
• W2106171330 cites W2058593051 @default.
• W2106171330 cites W2059675239 @default.
• W2106171330 cites W2060479231 @default.
• W2106171330 cites W2061967195 @default.
• W2106171330 cites W2067956931 @default.
• W2106171330 cites W2070446231 @default.
• W2106171330 cites W2074160776 @default.
• W2106171330 cites W2084990572 @default.
• W2106171330 cites W2089516987 @default.
• W2106171330 cites W2091364809 @default.
• W2106171330 cites W2094870572 @default.
• W2106171330 cites W2107425890 @default.
• W2106171330 cites W2127688157 @default.
• W2106171330 cites W2137118674 @default.
• W2106171330 cites W2138114398 @default.
• W2106171330 cites W2138387587 @default.
• W2106171330 cites W2147155927 @default.
• W2106171330 cites W2155531603 @default.
• W2106171330 cites W2159513257 @default.
• W2106171330 cites W2161074777 @default.
• W2106171330 cites W2401085244 @default.
• W2106171330 cites W4293247451 @default.
• W2106171330 doi "https://doi.org/10.1152/ajpheart.01327.2005" @default.
• W2106171330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16461369" @default.
• W2106171330 hasPublicationYear "2006" @default.
• W2106171330 type Work @default.
• W2106171330 sameAs 2106171330 @default.
• W2106171330 citedByCount "112" @default.
• W2106171330 countsByYear W21061713302012 @default.
• W2106171330 countsByYear W21061713302013 @default.
• W2106171330 countsByYear W21061713302014 @default.
• W2106171330 countsByYear W21061713302015 @default.
• W2106171330 countsByYear W21061713302016 @default.
• W2106171330 countsByYear W21061713302017 @default.
• W2106171330 countsByYear W21061713302018 @default.
• W2106171330 countsByYear W21061713302019 @default.
• W2106171330 countsByYear W21061713302020 @default.
• W2106171330 countsByYear W21061713302021 @default.
• W2106171330 countsByYear W21061713302022 @default.
• W2106171330 countsByYear W21061713302023 @default.
• W2106171330 crossrefType "journal-article" @default.
• W2106171330 hasAuthorship W2106171330A5005716248 @default.
• W2106171330 hasAuthorship W2106171330A5027847601 @default.
• W2106171330 hasAuthorship W2106171330A5048278410 @default.
• W2106171330 hasConcept C111566952 @default.
• W2106171330 hasConcept C126322002 @default.
• W2106171330 hasConcept C134018914 @default.
• W2106171330 hasConcept C141071460 @default.
• W2106171330 hasConcept C164705383 @default.
• W2106171330 hasConcept C17991360 @default.
• W2106171330 hasConcept C2775944032 @default.
• W2106171330 hasConcept C2778198053 @default.
• W2106171330 hasConcept C2778690821 @default.
• W2106171330 hasConcept C49453240 @default.
• W2106171330 hasConcept C500558357 @default.
• W2106171330 hasConcept C64943373 @default.
• W2106171330 hasConcept C71924100 @default.
• W2106171330 hasConceptScore W2106171330C111566952 @default.
• W2106171330 hasConceptScore W2106171330C126322002 @default.
• W2106171330 hasConceptScore W2106171330C134018914 @default.
• W2106171330 hasConceptScore W2106171330C141071460 @default.
• W2106171330 hasConceptScore W2106171330C164705383 @default.
• W2106171330 hasConceptScore W2106171330C17991360 @default.
• W2106171330 hasConceptScore W2106171330C2775944032 @default.
• W2106171330 hasConceptScore W2106171330C2778198053 @default.
• W2106171330 hasConceptScore W2106171330C2778690821 @default.
• W2106171330 hasConceptScore W2106171330C49453240 @default.
• W2106171330 hasConceptScore W2106171330C500558357 @default.
• W2106171330 hasConceptScore W2106171330C64943373 @default.
• W2106171330 hasConceptScore W2106171330C71924100 @default.
• W2106171330 hasIssue "1" @default.
• W2106171330 hasLocation W21061713301 @default.

• next