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• W2106171938 abstract "Mizolastine, an antihistamine pharmaceutical, was found to significantly inhibit larval settlement of the barnacle Amphibalanus (=Balanus) amphitrite, the bryozoan Bugula neritina, and the polychaete Hydroides elegans with EC50 values of 4.2, 11.2, and 4.1 µg ml−1, respectively. No toxicity against the larvae of these three species was observed at the concentration range tested during incubations with mizolastine. To determine whether the anti-settlement activity of mizolastine is reversible, recovery bioassays using these three species were conducted. More than 70% of the larvae that had been exposed for 4 h to mizolastine at concentrations four-fold greater than their respective EC50 values completed normal metamorphosis. The results of the recovery bioassay provide evidence that the anti-settlement effect of mizolastine is reversible in addition to being nontoxic. The anti-settlement activities of several intermediates of the synthesis process of mizolastine were also examined. One of the intermediates, 2-chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole, inhibited larval settlement and metamorphosis with low toxicity. These results may improve the understanding of the key functional group responsible for the anti-settlement activity of mizolastine." @default.
• W2106171938 created "2016-06-24" @default.
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• W2106171938 date "2009-07-24" @default.
• W2106171938 modified "2023-10-17" @default.
• W2106171938 title "Reversible anti-settlement activity against<i>Amphibalanus</i>(=<i>Balanus</i>)<i>amphitrite, Bugula neritina</i>, and<i>Hydroides elegans</i>by a nontoxic pharmaceutical compound, mizolastine" @default.
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• W2106171938 doi "https://doi.org/10.1080/08927010903154724" @default.
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