FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106172009> ?p ?o ?g. }

• W2106172009 abstract "Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by motor dysfunction of the lower extremities and urinary disturbance. Immunomodulatory treatments are the main strategy for HAM/TSP, but several issues are associated with long-term treatment. We conducted a clinical trial with prosultiamine (which has apoptotic activity against HTLV-I-infected cells) as a novel therapy in HAM/TSP patients. We enrolled 24 HAM/TSP patients in this open-label clinical trial. Prosultiamine (300 mg, orally) was administered once daily for 12 weeks. We monitored changes in the motor function of the lower extremities and urinary function as well as copy numbers of the HTLV-I provirus in peripheral blood mononuclear cells (PBMCs). Improvement in the motor function of the lower extremities based on a reduction in spasticity (for example, decrease in time required for walking and descending a flight of stairs) was observed. In an urodynamic study (UDS), bladder capacity and detrusor pressure and then maximum flow rate increased significantly. Detrusor overactivity and detrusor-sphincter dyssynergia improved in 68.8% and 45.5% of patients observed at pretreatment, respectively. Improvement in UDS corresponded with improvements in the score of nocturia-quality of life questionnaire. HTLV-I proviral copy numbers in PBMCs decreased significantly (approximately 15.4%) compared with pretreatment levels. These data suggest that prosultiamine can safely improve motor dysfunction of the lower extremities and urinary disturbance as well as reduce HTLV-I provirus levels in peripheral blood. It therefore has potential as a new therapeutic tool for HAM/TSP patients. University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) number, UMIN000005969 . Please see related commentary: http://www.biomedcentral.com/1741-7015/11/183 ." @default.
• W2106172009 created "2016-06-24" @default.
• W2106172009 creator A5001568893 @default.
• W2106172009 creator A5016544055 @default.
• W2106172009 creator A5016823828 @default.
• W2106172009 creator A5024057178 @default.
• W2106172009 creator A5025714734 @default.
• W2106172009 creator A5052000092 @default.
• W2106172009 creator A5055072474 @default.
• W2106172009 creator A5063420183 @default.
• W2106172009 creator A5070326257 @default.
• W2106172009 creator A5074074813 @default.
• W2106172009 creator A5076025150 @default.
• W2106172009 creator A5079627883 @default.
• W2106172009 creator A5081071954 @default.
• W2106172009 creator A5084299259 @default.
• W2106172009 creator A5084815637 @default.
• W2106172009 date "2013-08-15" @default.
• W2106172009 modified "2023-10-08" @default.
• W2106172009 title "Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial" @default.
• W2106172009 cites W1756380997 @default.
• W2106172009 cites W1978771608 @default.
• W2106172009 cites W1985326180 @default.
• W2106172009 cites W1991941671 @default.
• W2106172009 cites W2006425798 @default.
• W2106172009 cites W2015519667 @default.
• W2106172009 cites W2030973107 @default.
• W2106172009 cites W2033950199 @default.
• W2106172009 cites W2053107516 @default.
• W2106172009 cites W2069993170 @default.
• W2106172009 cites W2081361527 @default.
• W2106172009 cites W2096172083 @default.
• W2106172009 cites W2130873978 @default.
• W2106172009 cites W2154664865 @default.
• W2106172009 cites W2171789198 @default.
• W2106172009 cites W2336211911 @default.
• W2106172009 cites W2511464904 @default.
• W2106172009 doi "https://doi.org/10.1186/1741-7015-11-182" @default.
• W2106172009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3826868" @default.
• W2106172009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23945290" @default.
• W2106172009 hasPublicationYear "2013" @default.
• W2106172009 type Work @default.
• W2106172009 sameAs 2106172009 @default.
• W2106172009 citedByCount "15" @default.
• W2106172009 countsByYear W21061720092013 @default.
• W2106172009 countsByYear W21061720092015 @default.
• W2106172009 countsByYear W21061720092016 @default.
• W2106172009 countsByYear W21061720092017 @default.
• W2106172009 countsByYear W21061720092018 @default.
• W2106172009 countsByYear W21061720092020 @default.
• W2106172009 countsByYear W21061720092021 @default.
• W2106172009 countsByYear W21061720092023 @default.
• W2106172009 crossrefType "journal-article" @default.
• W2106172009 hasAuthorship W2106172009A5001568893 @default.
• W2106172009 hasAuthorship W2106172009A5016544055 @default.
• W2106172009 hasAuthorship W2106172009A5016823828 @default.
• W2106172009 hasAuthorship W2106172009A5024057178 @default.
• W2106172009 hasAuthorship W2106172009A5025714734 @default.
• W2106172009 hasAuthorship W2106172009A5052000092 @default.
• W2106172009 hasAuthorship W2106172009A5055072474 @default.
• W2106172009 hasAuthorship W2106172009A5063420183 @default.
• W2106172009 hasAuthorship W2106172009A5070326257 @default.
• W2106172009 hasAuthorship W2106172009A5074074813 @default.
• W2106172009 hasAuthorship W2106172009A5076025150 @default.
• W2106172009 hasAuthorship W2106172009A5079627883 @default.
• W2106172009 hasAuthorship W2106172009A5081071954 @default.
• W2106172009 hasAuthorship W2106172009A5084299259 @default.
• W2106172009 hasAuthorship W2106172009A5084815637 @default.
• W2106172009 hasBestOaLocation W21061720091 @default.
• W2106172009 hasConcept C118552586 @default.
• W2106172009 hasConcept C126322002 @default.
• W2106172009 hasConcept C2776368728 @default.
• W2106172009 hasConcept C2776392238 @default.
• W2106172009 hasConcept C2777604421 @default.
• W2106172009 hasConcept C2779012798 @default.
• W2106172009 hasConcept C2780775167 @default.
• W2106172009 hasConcept C2781045395 @default.
• W2106172009 hasConcept C42219234 @default.
• W2106172009 hasConcept C71924100 @default.
• W2106172009 hasConcept C77411442 @default.
• W2106172009 hasConcept C90924648 @default.
• W2106172009 hasConceptScore W2106172009C118552586 @default.
• W2106172009 hasConceptScore W2106172009C126322002 @default.
• W2106172009 hasConceptScore W2106172009C2776368728 @default.
• W2106172009 hasConceptScore W2106172009C2776392238 @default.
• W2106172009 hasConceptScore W2106172009C2777604421 @default.
• W2106172009 hasConceptScore W2106172009C2779012798 @default.
• W2106172009 hasConceptScore W2106172009C2780775167 @default.
• W2106172009 hasConceptScore W2106172009C2781045395 @default.
• W2106172009 hasConceptScore W2106172009C42219234 @default.
• W2106172009 hasConceptScore W2106172009C71924100 @default.
• W2106172009 hasConceptScore W2106172009C77411442 @default.
• W2106172009 hasConceptScore W2106172009C90924648 @default.
• W2106172009 hasIssue "1" @default.
• W2106172009 hasLocation W21061720091 @default.
• W2106172009 hasLocation W21061720092 @default.
• W2106172009 hasLocation W21061720093 @default.
• W2106172009 hasLocation W21061720094 @default.
• W2106172009 hasLocation W21061720095 @default.
• W2106172009 hasOpenAccess W2106172009 @default.

• next