Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106175478> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2106175478 endingPage "1184" @default.
- W2106175478 startingPage "1179" @default.
- W2106175478 abstract "Nonhemolytic transfusion reactions (NHTRs) frequently occur after platelet transfusions. White cell (WBC)-derived inflammatory cytokines can cause these reactions, but they are rarely found in WBC-poor platelet preparations. Transfusion reactions were investigated with regard to the residual WBC content in the stored platelet concentrate in two consecutive study periods.In the first study period, platelet concentrates were WBC-reduced by bedside filtration. In the second period, all platelet concentrates were filtered before storage. Recipients who experienced transfusion reactions were examined with regard to their main clinical symptoms during and after transfusion. In the supernatant of the involved platelet concentrates, concentrations of interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor (TNF)alpha, macrophage inflammatory protein 1alpha, and RANTES were analyzed.The incidence of transfusion reactions remained steady when the transfusion regimen was changed from bedside filtration to prestorage WBC filtration (1.63% and 1.56%; p = 0.84). In both periods, NHTRs were predominantly of allergic origin. Inflammatory mediators IL-1beta, IL-6, IL-8, and TNFalpha were detectable in only a minority of platelet components involved in NHTRs. Platelet concentrates involved in allergic reactions contained high concentrations of RANTES (668 +/- 223 ng/mL).Prestorage WBC filtration did not reduce the incidence of these reactions, and inflammatory cytokines were of minor relevance. The proinflammatory platelet-derived chemokine RANTES, which accumulates even in WBC-reduced platelet concentrates, was associated with allergic transfusion reactions. Platelet-derived mediators may be a key to understanding NHTRs." @default.
- W2106175478 created "2016-06-24" @default.
- W2106175478 creator A5010850187 @default.
- W2106175478 creator A5043991897 @default.
- W2106175478 creator A5054520048 @default.
- W2106175478 creator A5071480424 @default.
- W2106175478 date "1999-11-12" @default.
- W2106175478 modified "2023-09-26" @default.
- W2106175478 title "Febrile and allergic transfusion reactions after the transfusion of white cell-poor platelet preparations" @default.
- W2106175478 cites W1480920464 @default.
- W2106175478 cites W1965242977 @default.
- W2106175478 cites W1969658034 @default.
- W2106175478 cites W1976064940 @default.
- W2106175478 cites W1976613518 @default.
- W2106175478 cites W1980560220 @default.
- W2106175478 cites W1984929155 @default.
- W2106175478 cites W2003524073 @default.
- W2106175478 cites W2006400525 @default.
- W2106175478 cites W2009463918 @default.
- W2106175478 cites W2023602786 @default.
- W2106175478 cites W2024044064 @default.
- W2106175478 cites W2027344845 @default.
- W2106175478 cites W2030279593 @default.
- W2106175478 cites W2052377415 @default.
- W2106175478 cites W2072479185 @default.
- W2106175478 cites W2075346991 @default.
- W2106175478 cites W2082308378 @default.
- W2106175478 cites W2092930088 @default.
- W2106175478 cites W2096171902 @default.
- W2106175478 cites W2112293155 @default.
- W2106175478 cites W2126093939 @default.
- W2106175478 cites W2132879755 @default.
- W2106175478 cites W2139439820 @default.
- W2106175478 cites W2141224996 @default.
- W2106175478 cites W2143800769 @default.
- W2106175478 cites W2146347312 @default.
- W2106175478 cites W4230711098 @default.
- W2106175478 cites W2007496877 @default.
- W2106175478 doi "https://doi.org/10.1046/j.1537-2995.1999.39111179.x" @default.
- W2106175478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10604243" @default.
- W2106175478 hasPublicationYear "1999" @default.
- W2106175478 type Work @default.
- W2106175478 sameAs 2106175478 @default.
- W2106175478 citedByCount "97" @default.
- W2106175478 countsByYear W21061754782012 @default.
- W2106175478 countsByYear W21061754782013 @default.
- W2106175478 countsByYear W21061754782014 @default.
- W2106175478 countsByYear W21061754782015 @default.
- W2106175478 countsByYear W21061754782016 @default.
- W2106175478 countsByYear W21061754782017 @default.
- W2106175478 countsByYear W21061754782018 @default.
- W2106175478 countsByYear W21061754782020 @default.
- W2106175478 countsByYear W21061754782021 @default.
- W2106175478 countsByYear W21061754782022 @default.
- W2106175478 countsByYear W21061754782023 @default.
- W2106175478 crossrefType "journal-article" @default.
- W2106175478 hasAuthorship W2106175478A5010850187 @default.
- W2106175478 hasAuthorship W2106175478A5043991897 @default.
- W2106175478 hasAuthorship W2106175478A5054520048 @default.
- W2106175478 hasAuthorship W2106175478A5071480424 @default.
- W2106175478 hasConcept C13373296 @default.
- W2106175478 hasConcept C164027704 @default.
- W2106175478 hasConcept C17991360 @default.
- W2106175478 hasConcept C203014093 @default.
- W2106175478 hasConcept C2776689292 @default.
- W2106175478 hasConcept C2776914184 @default.
- W2106175478 hasConcept C2778488018 @default.
- W2106175478 hasConcept C71924100 @default.
- W2106175478 hasConcept C89560881 @default.
- W2106175478 hasConceptScore W2106175478C13373296 @default.
- W2106175478 hasConceptScore W2106175478C164027704 @default.
- W2106175478 hasConceptScore W2106175478C17991360 @default.
- W2106175478 hasConceptScore W2106175478C203014093 @default.
- W2106175478 hasConceptScore W2106175478C2776689292 @default.
- W2106175478 hasConceptScore W2106175478C2776914184 @default.
- W2106175478 hasConceptScore W2106175478C2778488018 @default.
- W2106175478 hasConceptScore W2106175478C71924100 @default.
- W2106175478 hasConceptScore W2106175478C89560881 @default.
- W2106175478 hasIssue "11-12" @default.
- W2106175478 hasLocation W21061754781 @default.
- W2106175478 hasLocation W21061754782 @default.
- W2106175478 hasOpenAccess W2106175478 @default.
- W2106175478 hasPrimaryLocation W21061754781 @default.
- W2106175478 hasRelatedWork W1984508338 @default.
- W2106175478 hasRelatedWork W1986099997 @default.
- W2106175478 hasRelatedWork W2092481568 @default.
- W2106175478 hasRelatedWork W2111945182 @default.
- W2106175478 hasRelatedWork W2142591538 @default.
- W2106175478 hasRelatedWork W2168966876 @default.
- W2106175478 hasRelatedWork W2354522787 @default.
- W2106175478 hasRelatedWork W2738799901 @default.
- W2106175478 hasRelatedWork W94177391 @default.
- W2106175478 hasRelatedWork W2102532225 @default.
- W2106175478 hasVolume "39" @default.
- W2106175478 isParatext "false" @default.
- W2106175478 isRetracted "false" @default.
- W2106175478 magId "2106175478" @default.
- W2106175478 workType "article" @default.