FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106180180> ?p ?o ?g. }

• W2106180180 endingPage "2075" @default.
• W2106180180 startingPage "2066" @default.
• W2106180180 abstract "Abstract There is an increasing demand for the development of intermediate biomarkers to assess colon cancer risk. We previously determined that a live cell bioassay, which assesses apoptosis resistance in the nonneoplastic colonic mucosa, detects ∼50% of patients with colon cancer. A hypothesis-driven biomarker that reflects apoptosis resistance in routine formalin-fixed, paraffin-embedded tissue would be easier to use. Cytochrome c oxidase is a critical enzyme that controls mitochondrial respiration and is central to apoptosis. We did an immunohistochemical study of cytochrome c oxidase subunit I expression in 46 colonic mucosal samples from 16 patients who had undergone a colonic resection. These included five patients without evidence of colonic neoplasia (three normal and two diverticulitis), three patients with tubulovillous adenomas, and eight patients with colonic adenocarcinomas. Analysis of aberrancies in expression of cytochrome c oxidase subunit I showed that, compared with nonneoplasia, the patients with neoplasia had a higher mean incidence of crypts having decreased expression (1.7 versus 22.8, P = 0.03) and a higher mean incidence having crypt-restricted loss (0.6 versus 3.2, P = 0.06). The percentage with segmented loss was low and was similar in the two groups. Combining these results, the mean % normal (i.e., with none of the three types of abnormality) was 96.7 in nonneoplasia versus only 73.2 in patients with neoplasia (P = 0.02). It should be noted that a defect in cytochrome c oxidase subunit I immunostaining was not detected in all biopsy samples from each patient for whom some abnormality was found, indicating a “patchiness” in the cytochrome c oxidase subunit I field defect. As a result of this “patchiness,” the increased variability in the incidence of crypt-restricted loss of cytochrome c oxidase subunit I expression was a statistically significant feature of the neoplasia group. Crypt-restricted loss of cytochrome c oxidase subunit I has not been previously reported in colonic mucosa and is presumably the result of a crypt-restricted stem cell mutation. Decreased cytochrome c oxidase subunit I expression also significantly correlated with apoptosis resistance, a factor known to contribute to carcinogenesis. The results suggest, however, that aberrant cytochrome c oxidase subunit I expression may be a better biomarker than loss of apoptosis competence for increased colon cancer risk." @default.
• W2106180180 created "2016-06-24" @default.
• W2106180180 creator A5007767990 @default.
• W2106180180 creator A5011628252 @default.
• W2106180180 creator A5015197495 @default.
• W2106180180 creator A5020458397 @default.
• W2106180180 creator A5044285874 @default.
• W2106180180 creator A5051438661 @default.
• W2106180180 creator A5062522223 @default.
• W2106180180 creator A5066095968 @default.
• W2106180180 creator A5070153214 @default.
• W2106180180 creator A5074529972 @default.
• W2106180180 creator A5082539819 @default.
• W2106180180 date "2005-09-01" @default.
• W2106180180 modified "2023-10-15" @default.
• W2106180180 title "Crypt-Restricted Loss and Decreased Protein Expression of Cytochrome <i>c</i> Oxidase Subunit I as Potential Hypothesis-Driven Biomarkers of Colon Cancer Risk" @default.
• W2106180180 cites W1522763255 @default.
• W2106180180 cites W1591646293 @default.
• W2106180180 cites W1748754899 @default.
• W2106180180 cites W1751574485 @default.
• W2106180180 cites W1784425676 @default.
• W2106180180 cites W1802480460 @default.
• W2106180180 cites W183829867 @default.
• W2106180180 cites W1965151763 @default.
• W2106180180 cites W1966800933 @default.
• W2106180180 cites W1981409857 @default.
• W2106180180 cites W1984073255 @default.
• W2106180180 cites W1988357599 @default.
• W2106180180 cites W1989821468 @default.
• W2106180180 cites W1990411057 @default.
• W2106180180 cites W1991807136 @default.
• W2106180180 cites W1993772997 @default.
• W2106180180 cites W1993838015 @default.
• W2106180180 cites W1995795300 @default.
• W2106180180 cites W2000605323 @default.
• W2106180180 cites W2002926498 @default.
• W2106180180 cites W2018616240 @default.
• W2106180180 cites W2021207588 @default.
• W2106180180 cites W2022380356 @default.
• W2106180180 cites W2024018307 @default.
• W2106180180 cites W2024472871 @default.
• W2106180180 cites W2029401533 @default.
• W2106180180 cites W2033729587 @default.
• W2106180180 cites W2034396713 @default.
• W2106180180 cites W2034744093 @default.
• W2106180180 cites W2039540766 @default.
• W2106180180 cites W2039639418 @default.
• W2106180180 cites W2043015105 @default.
• W2106180180 cites W2045157181 @default.
• W2106180180 cites W2045735728 @default.
• W2106180180 cites W2048328091 @default.
• W2106180180 cites W2049528479 @default.
• W2106180180 cites W2051500471 @default.
• W2106180180 cites W2052417279 @default.
• W2106180180 cites W2057030383 @default.
• W2106180180 cites W2057509964 @default.
• W2106180180 cites W2067908763 @default.
• W2106180180 cites W2068799885 @default.
• W2106180180 cites W2071221374 @default.
• W2106180180 cites W2071469209 @default.
• W2106180180 cites W2071584014 @default.
• W2106180180 cites W2072697398 @default.
• W2106180180 cites W2075796686 @default.
• W2106180180 cites W2077701124 @default.
• W2106180180 cites W2081927508 @default.
• W2106180180 cites W2082514251 @default.
• W2106180180 cites W2083796146 @default.
• W2106180180 cites W2083854831 @default.
• W2106180180 cites W2092265444 @default.
• W2106180180 cites W2093530916 @default.
• W2106180180 cites W2093686699 @default.
• W2106180180 cites W2096794529 @default.
• W2106180180 cites W2099240520 @default.
• W2106180180 cites W2100644018 @default.
• W2106180180 cites W2103782088 @default.
• W2106180180 cites W2108086395 @default.
• W2106180180 cites W2109528024 @default.
• W2106180180 cites W2114349736 @default.
• W2106180180 cites W2122813711 @default.
• W2106180180 cites W2126737200 @default.
• W2106180180 cites W2129945440 @default.
• W2106180180 cites W2133856203 @default.
• W2106180180 cites W2143339542 @default.
• W2106180180 cites W2144687501 @default.
• W2106180180 cites W2153556651 @default.
• W2106180180 cites W2158615962 @default.
• W2106180180 cites W2158899015 @default.
• W2106180180 cites W2184995059 @default.
• W2106180180 cites W2325660013 @default.
• W2106180180 cites W2333079922 @default.
• W2106180180 cites W4248334199 @default.
• W2106180180 doi "https://doi.org/10.1158/1055-9965.epi-05-0180" @default.
• W2106180180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16172211" @default.
• W2106180180 hasPublicationYear "2005" @default.
• W2106180180 type Work @default.
• W2106180180 sameAs 2106180180 @default.
• W2106180180 citedByCount "39" @default.
• W2106180180 countsByYear W21061801802012 @default.

• next