Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106180265> ?p ?o ?g. }
- W2106180265 endingPage "996" @default.
- W2106180265 startingPage "984" @default.
- W2106180265 abstract "G protein-coupled receptors (GPCRs) play pivotal roles in regulating various cellular functions. Although many GPCRs induce NF-kappaB activation, the molecular mechanism of GPCR-induced NF-kappaB activation remains largely unknown. CARMA3 (CARD and MAGUK domain-containing protein 3) is a scaffold molecule with unknown biological functions. By generating CARMA3 knockout mice using the gene targeting approach, here we show CARMA3 is required for GPCR-induced NF-kappaB activation. Mechanistically, we found that CARMA3 deficiency impairs GPCR-induced IkappaB kinase (IKK) activation, although it does not affect GPCR-induced IKKalpha/beta phosphorylation, indicating that inducible phosphorylation of IKKalpha/beta alone is not sufficient to induce its kinase activity. We also found that CARMA3 is physically associated with NEMO/IKKgamma, and induces polyubiquitination of an unknown protein(s) that associates with NEMO, likely by linking NEMO to TRAF6. Consistently, we found TRAF6 deficiency also abrogates GPCR-induced NF-kappaB activation. Together, our results provide the genetic evidence that CARMA3 is required for GPCR-induced NF-kappaB activation." @default.
- W2106180265 created "2016-06-24" @default.
- W2106180265 creator A5004983828 @default.
- W2106180265 creator A5018858811 @default.
- W2106180265 creator A5027629181 @default.
- W2106180265 creator A5047226301 @default.
- W2106180265 creator A5047717810 @default.
- W2106180265 creator A5049585978 @default.
- W2106180265 creator A5052083872 @default.
- W2106180265 creator A5061145741 @default.
- W2106180265 creator A5082421105 @default.
- W2106180265 date "2007-04-15" @default.
- W2106180265 modified "2023-10-08" @default.
- W2106180265 title "CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-κB activation" @default.
- W2106180265 cites W1600472471 @default.
- W2106180265 cites W1621883807 @default.
- W2106180265 cites W1927579368 @default.
- W2106180265 cites W1970628654 @default.
- W2106180265 cites W1972509561 @default.
- W2106180265 cites W1975293480 @default.
- W2106180265 cites W1977642281 @default.
- W2106180265 cites W1988352469 @default.
- W2106180265 cites W1989844987 @default.
- W2106180265 cites W1991923928 @default.
- W2106180265 cites W1993687272 @default.
- W2106180265 cites W1994816216 @default.
- W2106180265 cites W2011211995 @default.
- W2106180265 cites W2016116811 @default.
- W2106180265 cites W2026863172 @default.
- W2106180265 cites W2029295983 @default.
- W2106180265 cites W2038349428 @default.
- W2106180265 cites W2039253450 @default.
- W2106180265 cites W2051509134 @default.
- W2106180265 cites W2055432260 @default.
- W2106180265 cites W2056402897 @default.
- W2106180265 cites W2063126618 @default.
- W2106180265 cites W2064565246 @default.
- W2106180265 cites W2066177415 @default.
- W2106180265 cites W2072666747 @default.
- W2106180265 cites W2074362469 @default.
- W2106180265 cites W2075083870 @default.
- W2106180265 cites W2075626786 @default.
- W2106180265 cites W2080875376 @default.
- W2106180265 cites W2083498707 @default.
- W2106180265 cites W2086900079 @default.
- W2106180265 cites W2091834956 @default.
- W2106180265 cites W2096977835 @default.
- W2106180265 cites W2105074631 @default.
- W2106180265 cites W2106877484 @default.
- W2106180265 cites W2107396952 @default.
- W2106180265 cites W2112881364 @default.
- W2106180265 cites W2113285011 @default.
- W2106180265 cites W2115399372 @default.
- W2106180265 cites W2117095174 @default.
- W2106180265 cites W2131577319 @default.
- W2106180265 cites W2141125657 @default.
- W2106180265 cites W2147921405 @default.
- W2106180265 cites W2148119611 @default.
- W2106180265 cites W2159460252 @default.
- W2106180265 cites W2170720109 @default.
- W2106180265 cites W2227064725 @default.
- W2106180265 doi "https://doi.org/10.1101/gad.1502507" @default.
- W2106180265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1847715" @default.
- W2106180265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17438001" @default.
- W2106180265 hasPublicationYear "2007" @default.
- W2106180265 type Work @default.
- W2106180265 sameAs 2106180265 @default.
- W2106180265 citedByCount "118" @default.
- W2106180265 countsByYear W21061802652012 @default.
- W2106180265 countsByYear W21061802652013 @default.
- W2106180265 countsByYear W21061802652014 @default.
- W2106180265 countsByYear W21061802652015 @default.
- W2106180265 countsByYear W21061802652016 @default.
- W2106180265 countsByYear W21061802652017 @default.
- W2106180265 countsByYear W21061802652018 @default.
- W2106180265 countsByYear W21061802652019 @default.
- W2106180265 countsByYear W21061802652020 @default.
- W2106180265 countsByYear W21061802652021 @default.
- W2106180265 countsByYear W21061802652022 @default.
- W2106180265 countsByYear W21061802652023 @default.
- W2106180265 crossrefType "journal-article" @default.
- W2106180265 hasAuthorship W2106180265A5004983828 @default.
- W2106180265 hasAuthorship W2106180265A5018858811 @default.
- W2106180265 hasAuthorship W2106180265A5027629181 @default.
- W2106180265 hasAuthorship W2106180265A5047226301 @default.
- W2106180265 hasAuthorship W2106180265A5047717810 @default.
- W2106180265 hasAuthorship W2106180265A5049585978 @default.
- W2106180265 hasAuthorship W2106180265A5052083872 @default.
- W2106180265 hasAuthorship W2106180265A5061145741 @default.
- W2106180265 hasAuthorship W2106180265A5082421105 @default.
- W2106180265 hasBestOaLocation W21061802651 @default.
- W2106180265 hasConcept C100175707 @default.
- W2106180265 hasConcept C104317684 @default.
- W2106180265 hasConcept C11960822 @default.
- W2106180265 hasConcept C135285700 @default.
- W2106180265 hasConcept C170493617 @default.
- W2106180265 hasConcept C184235292 @default.
- W2106180265 hasConcept C25602115 @default.