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- W2106180867 abstract "The natural omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), has recently been credited for possessing anticancer properties. Herein, we investigate the cytotoxic actions of DHA-loaded low-density lipoprotein (LDL) nanoparticles in normal and liver cancer cells.LDL-DHA nanoparticles were prepared and subjected to extensive biophysical characterization. The therapeutic utility of LDL-DHA nanoparticles was evaluated in normal and malignant murine hepatocyte cell lines, TIB-73 and TIB-75, respectively.The engineered LDL-DHA nanoparticles possessed enhanced physical and oxidative stabilities over native LDL and free DHA. Dose-response studies showed that therapeutic doses of LDL-DHA nanoparticles that completely killed TIB-75 were innocuous to TIB-73. The selective induction of lipid peroxidation and reactive oxygen species in the cancer cells was shown to play a central role in LDL-DHA nanoparticle-mediated cytotoxicity.In summary, these findings indicate that LDL-DHA nanoparticles show great promise as a selective anticancer agent against hepatocellular carcinoma." @default.
- W2106180867 created "2016-06-24" @default.
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- W2106180867 creator A5055858624 @default.
- W2106180867 creator A5080586179 @default.
- W2106180867 date "2014-07-01" @default.
- W2106180867 modified "2023-10-01" @default.
- W2106180867 title "Low-density lipoprotein-mediated delivery of docosahexaenoic acid selectively kills murine liver cancer cells" @default.
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- W2106180867 doi "https://doi.org/10.2217/nnm.13.187" @default.
- W2106180867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4156561" @default.
- W2106180867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24397600" @default.
- W2106180867 hasPublicationYear "2014" @default.
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